Dengue Cases Significantly Decrease in the Americas

Following a record-setting 2024, new data indicate the extensive Dengue fever outbreak has been significantly reduced this year.

According to the Pan American Health Organization (PAHO) epidemiological week #34 report of 2025, a total of 3,740,133 suspected cases of Dengue were confirmed.

This represents a 68% decrease in mosquito-transmitted viral infections compared to the same period in 2024.

Unfortunately, a total of 1,886 Dengue-related fatalities have been recorded this year.

To provide local details, the PAHO published a subregion Dengue outbreak analysis on September 15, 2025, which is as follows:

Central America and México Sub-region. A total of 5,458 new suspected dengue cases were registered in EW 34. As of this week, the subregion exhibits a decrease of 74% compared to the same week in 2024 and 32% compared to the average of the last five years. The cases reported this week by Costa Rica represent an increment of 49%, Belize of 44%, México of 16% compared to the previous four epidemiological weeks.

Caribbean Sub-region. Forty-nine new suspected dengue cases were registered in EW 34. As of this week, the subregion has experienced a 52% decrease compared to the same week in 2024 and a 20% decrease compared to the average of the last five years.

Andean Sub-region. In EW 34, 2,238 new suspected dengue cases were registered. As of this week, the subregion exhibits a decrease of 64% compared to the same week in 2024 and 25% compared to the average of the last five years. The cases reported this week in Peru represent a 52% increase compared to the previous four epidemiological weeks.

Southern Cone Sub-region. A total of 19,086 new suspected dengue cases were reported in EW 34. As of this week, the subregion has experienced a 68% decrease compared to the same week in 2024.

While this PAHO data is a welcome relief from the 13 million Dengue cases reported in 2024, the health agency did not offer any guidance as to why this recent decrease is occurring.

To assist international travelers in planning their next trip, the U.S. CDC updated its Global Dengue outbreak Travel Health Advisory on September 16, 2026. This Level 1 advisory identified five cases in the America, and 17 worldwide.

Of note, Cuba was identified by the CDC as a source for travel-related Dengue infections.

This data is validated by the Florida Department of Health, which reports that about 110 travel-related cases in the Miami-Dade County area are related to travelers from Cuba.

During the summer of 2025, the CDC advised clinicians to enhance the evaluation of international traveling patients for Dengue infections.

From a disease prevention perspective, currently, Dengue vaccines are unavailable in the U.S. mainland, but are expected to be available in various countries in the second half of 2025.