The first volunteer has received a dose in Oxford Vaccine Group's first-in-human trial of the Lassa vaccine, marking a significant milestone in the fight against the deadly virus, which was first discovered in the late 1960s.
The trial, funded by the Coalition for Epidemic Preparedness Innovations, will assess the safety and immune response of the ChAdOx1 Lassa vaccine.
Commenting on the launch of the trial, Professor Maheshi Ramasamy, Chief Investigator of the trial at the Oxford Vaccine Group, commented in a press release on December 4, 2025, "Vaccines are one of the most powerful tools we have in global health: they save lives, stop outbreaks, and strengthen health systems, and so we're delighted to start the VITAL01 Lassa fever vaccine study here in Oxford."
The World Health Organization has identified Lassa fever and related viruses as priority pathogens in urgent need of research and development because they pose a significant public health risk due to their potential to cause large outbreaks. Experts estimate that up to 700 million people could live in regions at risk of Lassa fever by 2070, although there are currently no licensed vaccines or treatments for Lassa fever.
In addition to the launch of new clinical trials, plans to advance a Lassa vaccine to licensure are progressing through regional leadership and coordination by the Lassa fever Coalition.














