Mosquito-Transmitted Diseases Need An Integrated Management Approach

With over 5.6 billion people worldwide at risk of arboviral infections, such as chikungunya, dengue, Zika, and yellow fever, healthcare professionals require access to the latest, evidence-based recommendations to manage these infections effectively in patients.

On July 4, 2025, the World Health Organization (WHO) released the Integrated Guidelines on the Clinical Management of Arboviral Diseases, providing clinical management recommendations for four of the most widespread arboviruses that affect humans.

The WHO says an integrated approach is vital, as these four diseases often present with similar symptoms, especially in the early stages of infection, and multiple arboviruses may circulate simultaneously in certain regions.

This makes clinical differentiation particularly challenging, especially when diagnostic testing is not readily available.

For example, the Federative Republic of Brazil continues to detect these mosquito-transmitted diseases in its cities, beaches, and mountain areas, where testing facilities are scarce.

As a disease prevention option, travel vaccines are available in 2025 targeting chikungunya, dengue, and yellow fever, but not for Zika.