Coronavirus Breaking News

The coronavirus disease COVID-19 is currently reaching pandemic levels in various countries.

Apr 9, 2025 • 5:30 am CDT
by Luis Silva

Shigellosis is the second leading cause of fatal diarrheal disease worldwide, strongly contributing to pediatric morbidity and mortality, without a U.S. FDA-approved vaccine available.

According to public health leaders and the Gates Foundation, developing an effective vaccine to prevent this deadly disease is essential in many areas worldwide.

To address this need, Valneva SE and LimmaTech Biologics AG today announced that the first participant has been vaccinated in a Phase 2 infant safety and immunogenicity study of Shigella4V2 (S4V2), the world's most clinically advanced tetravalent bioconjugate vaccine candidate against shigellosis. 

Dr. Juan Carlos, Chief Medical Officer of Valneva, commented in a press release on April 9, 2025, "Seeing so many infants and children dying from shigellosis is not acceptable if it can be prevented with a vaccine."

"As such, the development of Shigella vaccines has been identified as a priority by the World Health Organization and, in line with our mission of developing vaccines against infectious diseases with unmet medical needs, we are focused on delivering a preventative solution against this deadly disease." 

In the Phase 2 study S4V02, the safety and immunogenicity of S4V2 will be tested in approximately 110 nine-month-old infants to identify the best dose to be tested in a Phase 3 trial.

Sponsored and conducted by LimmaTech, S4V02 is a randomized, controlled, and blinded study conducted at a single study site in Kenya. Participants will receive a two-dose vaccination with one of two different vaccine dose levels of S4V2 or a control vaccine. Safety will be evaluated throughout the trial for approximately six months following the last vaccination.

Results of the phase 2 study, which is supported by funding from the Gates Foundation, are expected in the second half of 2025.

In November 2024, Valneva and LimmaTech launched a Phase 2b controlled human infection model (CHIM) study of S4V2 in healthy Shigella-naïve adults. This CHIM study forms part of the companies' staggered and risk-mitigating development strategy for S4V2, as it should provide the first results on efficacy before potentially advancing to further CHIM and Phase 3 studies.

Apr 8, 2025 • 1:18 pm CDT
Google Maps April 8, 2025

Mono County Public Health has confirmed a third fatality due to Hantavirus in the Town of Mammoth Lakes, a favorite outdoor destination for vacationers in Northeast California.

As of April 3, 2025, Mono County has recorded 27 cases since it was first reported here in 1993, the most in California. Twenty-one of these infections affected county residents, and six occurred among visitors who were infected in Mono. In 

As of 2022, 864 cases of Hantavirus disease were reported in the United States.

According to the U.S. CDC, Hantavirus is a serious and often fatal illness contracted through infected deer mouse droppings, urine, or saliva. It most commonly occurs in the late spring or summer.

“A third case of Hantavirus Pulmonary Syndrome (in 2025), each of which has been fatal, is tragic and alarming,” said Dr. Tom Boo, Mono County Public Health Officer, in a press release.

“We don’t have a clear sense of where this young adult may have contracted the virus. The home had no evidence of mouse activity. We observed some mice in the workplace, which is not unusual for indoor spaces this time of year in Mammoth Lakes.

We haven't identified any other activities in the weeks before illness that would have increased this person's exposure to mice or their droppings.

We’ve been aware of this suspected case for weeks, but obtaining testing has taken time. The occurrence of three cases in a short period has me worried, especially this early in the year.

We’ve gone about a month without additional suspect cases, but remain concerned about the increased activity.

We believe deer mouse numbers are high this year in Mammoth (Eastern Sierra). An increase in indoor mice elevates the risk of Hantavirus exposure.

As far as we know, none of these deceased individuals engaged in activities typically associated with exposure, such as cleaning out poorly ventilated indoor areas or outbuildings with a lot of mouse waste. Instead, these folks may have been exposed during normal daily activities in the home or the workplace.

Many of us encounter deer mice daily, and there is some risk. We should pay attention to the presence of mice and be careful around their waste,” stated Dr. Boo.

Without a preventive vaccine available in 2025, the county says to avoid eating food that may have been contaminated by rodents and always wash your hands thoroughly after any potential exposure.

Apr 8, 2025 • 4:36 am CDT
UKHSA April 7, 2025

The UK Health Security Agency (UKHSA) today announced it had detected a confirmed human case of Clade Ib mpox, in which the person who resides in the North East of England had no reported travel history and no reported link with previously reported mpox cases in the UK.

England has reported 11 mpox cases this year.

As of April 7, 2025, the UKHSA says the mpox risk to the UK population remains low, as clade Ia and Ib mpox are no longer classified as a high-consequence infectious disease.

To date, all previous cases in the UK have either been linked to someone who has traveled to an affected country or been linked to someone who has.

UKHSA Mpox Incident Director Dr Gillian Armstrong commented in a media release, "The risk to the UK population from mpox remains low."

"The majority of people who have presented with symptoms report close physical contact, including massages or sex, before developing symptoms."

"While mpox infection is mild for many, it can be severe for some, and UKHSA is committed to preventing its spread within the UK."

Currently, the UK government has authorized an approved mpox vaccine known as IMVAMUNE® (JYNNEOS®, MVA-BN®).

Whether you have travelled or not, it is essential to remain alert to the risks. Anyone who thinks they may have mpox should contact NHS 111 for advice on what to do, says the UKHSA.

Recently, the U.S. CDC updated its Level 2 Travel Health Advisory, saying, 'There is ongoing person-to-person transmission of mpox in Burundi, Central African Republic, Democratic Republic of the Congo, Kenya, the Republic of the Congo, Rwanda, Tanzania, Uganda, and Zambia.'

'Person-to-person transmission has occurred through various means during this outbreak.'

About 15 million people visited central Africa last year, many traveling from the U.S. and the UK.

The CDC, like the UK, recommends mpox vaccination for at-risk individuals.

Apr 8, 2025 • 4:14 am CDT
Sao Paulo Ministry of Health April 2025

The Pan American Health Organization (PAHO) recently updated its Dengue fever outbreak data dashboard, highlighting the continued surge of cases in 2025.

Within the Americas, the Federative Republic of Brazil's state of São Paulo is on track to exceed last year's record numbers.

As of April 8, 2025, São Paulo has reported approximately 522,000 dengue cases and 390 related fatalities, with an additional 475 deaths currently under investigation by the health ministry.

For all of 2024, over 9.6 million dengue cases and 5,441 related fatalities were reported throughout Brazil.

While Dengue has become endemic in the U.S. territories of Puerto Rico and the U.S. Virgin Islands, most cases in the United States are travel-related.

The U.S. Centers for Disease Control and Prevention (CDC) reported on April 2, 2025, that 1,346 travel-related Dengue cases and one local case have been reported in 30 jurisdictions this year.

Most of these cases were identified in southern Florida.

With over 6 million people visiting Brazil in 2024, and many international travelers returning to the U.S., identifying Dengue infections has become a challenge.

To offer updated guidance on Dengue testing, the CDC recently issued a Health Alert Network (HAN) Health Update to provide additional information to healthcare providers about the ongoing risk of dengue virus infections and updates to testing recommendations in the United States.

The CDC urges healthcare providers to continue taking steps to prevent, detect, diagnose, and respond to Dengue, as described in the June 2024 HAN Health Advisory (CDCHAN-00511).

Currently, the CDC does not recommend any Dengue vaccine in the U.S. However, second-generation Dengue vaccines are available in about 40 countries.

Apr 7, 2025 • 2:01 pm CDT
Google Maps April 7, 2025

The Department of Mayotte, an overseas department of France, recently announced that, due to the first indigenous (local) case of chikungunya on the island, health authorities are activating level 2A of the ORSEC (emergency) plan.

This decision will increase surveillance of the epidemiological situation and measures to prevent more active viral (virus) circulation by mosquitoes in the territory.

As of April 7, 2025, Mayotte has reported four chikungunya cases this year.

As a reminder, about 900 miles away, Reunion Island has been facing a chikungunya epidemic, with 13,594 cases, including two related fatalities, since August 2024.

Mayotte's Regional Health Agency says all travelers to and from Reunion Island should protect themselves from mosquito bites.

Mayotte is located between Africa's east coast and Madagascar, one of France's 18 regions.

To protect people on Reunion, the local government has started vaccinating 40,000 residents with a U.S. FDA-approved vaccine.

Valneva SE's IXCHIQ® Chikungunya vaccine is commercially available in the U.S. and recommended for travelers to endemic areas in 2025.

Apr 7, 2025 • 10:10 am CDT
WHO April 3, 2025

Two powerful earthquakes recently struck the central part of the Republic of the Union of Myanmar's Sagaing Region near Mandalay. The full scale of damage, deaths, and injuries has not yet been ascertained.

The World Health Organization's (WHO) Public Health Situation Analysis, released on April 3, 2025, says preliminary assessments indicate high casualties and trauma-related injuries, with an urgent need for emergency care. 

On April 2, 2025, the State Administration Council (SAC) reported that 3,003 people had died and 4,515 had been injured in the earthquake.

In the earthquake-affected areas, with limited access to safe water and worsening sanitation and hygiene conditions, the WHO says the risks for Acute Waterborne (AWD) - cholera outbreaks are assessed as very high. 

Since July 2024, AWD and cholera cases have surged in at least nine states, including Ayeyarwady, Bago, and Mandalay.

Mandalay, which faced a cholera outbreak in October 2024, remains at high risk for further outbreaks due to infrastructure damage and overcrowded shelters, significantly increasing the likelihood of cholera and other waterborne disease outbreaks.

From June 22, 2024, to March 23, 2025, 12,195 AWD cases (not all confirmed as cholera) were reported, along with three deaths.

A vaccination campaign using oral cholera vaccine (OCV) has been conducted in Yangon, Mon, and Mandalay, providing 2.4 million doses.

As of April 7, 2025, the U.S. CDC says, 'OCV vaccination may be considered for children and adults traveling to areas of active cholera transmission.'

In the United States, OCVs such as DUKORAL® are available at travel clinics and pharmacies.

The WHO wrote, 'These deteriorating conditions, combined with overcrowded temporary shelters and reduced sanitation services, significantly increase the risk of cholera and other waterborne disease outbreaks in the affected areas.'

Apr 7, 2025 • 9:38 am CDT
Texas DSHS April 4, 2025

During the measles outbreak of 2025, a second measles-related fatality was confirmed by the Texas Department of State Health Services (DSHS).

This school-aged child was hospitalized in Lubbock, Texas, was not vaccinated, had no reported underlying conditions, and passed away last week.

According to the child’s doctors, the condition was described as measles pulmonary failure.

As of April 7, 2025, 489 measles cases have been confirmed in Texas's South Plains and Panhandle regions this year.

DSHS’s interactive dashboard and additional information about the outbreak can be found on the News & Alerts page.

Globally, the U.S. CDC and the World Health Organization (WHO) have issued various measles outbreak advisories in 2025. The WHO says the 'source of this measles outbreak is unknown.'

The WHO and the CDC disclosed that genotype D8 and B3 sequences have been detected in 2025.

Apr 6, 2025 • 12:10 pm CDT
by Minyoung Kim

According to a new report from the World Health Organization (WHO), Dengue is a mosquito-borne viral infection that has caused significant increases in severe flu-like illness across the globe.

For example, the WHO's Western Pacific Region continues to face a high burden of Dengue-like Illnesses in the Republic of Fiji, an island country in the South Pacific Ocean.

Dengue Situation Update #720, published on April 3, 2025, shows that Fiji has reported over 800 cases of Dengue each of the last two weeks. This data indicates a significant increase above the five-year median of 300 monthly cases in the early part of most years.

This year's Dengue outbreak may upset vacationers planning to visit this unique destination in 2025. Fiji visitors reached a new high of over 900,000 in 2024, an increase of 5.7% compared to last year.

To forewarn international visitors in 2025, the U.S. CDC includes Fiji in its reissued Global Dengue Travel Health Advisory, which says people should avoid being bitten by a virus-carrying mosquito.

Since the WHO's Strategic Advisory Group of Experts on Immunization shared recommendations for use of the QDENGA® vaccine in October 2023, about 40 countries have authorized its use. However, the United States has yet to authorize this second-generation Dengue vaccine.

Apr 6, 2025 • 5:21 am CDT
The American Society for Microbiology

When visiting areas in central Asia, travelers may become ill with fevers and headaches, occasionally leading to acute encephalitis. According to local health ministries, the cause could be Nipah virus (NiV).

It is estimated that about 40% of people with NiV may die.

According to the UK Travel Health Pro on April 4, 2025, most human infections result from direct contact with animals, particularly pigs and bats, in a few Asian countries, such as Bangladesh, India, Malaysia, the Philippines, and Singapore.

For example, Bangladesh has already reported three cases of NiV in people this year.

In the Indian state of Kerala, the Health Department has started awareness activities ahead of the bat breeding season in five districts considered to be hotspots for the zoonotic infection: Kozhikode, Malappuram, Kannur, Wayanad, and Ernakulam. 

In 2023, Kerala experienced multiple Nipah outbreaks. Three of these outbreaks were contained to the Kozhikode district. 

However, the causes of these NiV outbreaks remain unclear.

While these outbreaks are concerning, the UK says the 'risk of NiV infection for tourists to endemic countries is currently very low, if the following precautions are taken.'

Unfortunately, NiV preventive vaccines are unavailable in 2025.

The World Health Organization says Nipah vaccine candidates include live-attenuated and replication-defective recombinant vaccine platforms based on poxviruses, VSV, adenovirus, measles, rabies, and virus-like particles and subunit vaccines. 

As of April 6, 2025, neither the U.S. Food and Drug Administration nor the European Medicines Agency has authorized a vaccine or treatment for Nipah, but clinical trials are ongoing. 

Apr 6, 2025 • 3:05 am CDT
© 2024 Walgreens Boots Alliance

While the U.S. CDC reports a continued decrease in influenza cases during the tail end of the 2024-2025 flu season, several cities are treating patients impacted by this respiratory disease.

According to the Wlagreens Flu Index®, the first week to show an increase in flu activity was the week ending on January 18, 2025.

Currently, the top ten cities treating people for the flu are:

  1. Harlingen-Weslaco-Brownsville-McAllen, Texas.
  2. New Orleans, La.
  3. Baton Rouge, La.
  4. Lafayette, La.
  5. El Paso, Texas (Las Cruces, N.M.)
  6. Chicago, Ill.
  7. Washington, D.C. (Hagerstown, Md.)
  8. Houston, Texas.
  9. Knoxville, Tenn.
  10. Honolulu, Hawaii.

For 11 years, the Walgreens Flu Index has provided an early and accurate view of disease trends. The Index offers detailed insights into flu activity across different markets.

This Index is based on retail prescription data for antiviral medications used to treat influenza at Walgreens locations nationwide. It is designed not to indicate the overall levels or severity of flu activity, but rather to highlight which populations are experiencing the highest incidence of influenza.

As of April 6, 2025, the CDC recommends flu shots for people at risk for this severe disease, especially for children. Unfortunately, there have been 168 influenza-associated deaths this flu season.

Flu shots remain available at most pharmacies throughout the United States.

Apr 5, 2025 • 4:13 am CDT
US CDC 2025

Nigeria’s Ministry of Health announced today that it has received over 1,000,000 doses of the pentavalent meningococcal conjugate vaccine (Men5CV) to combat the meningococcus C and W outbreak in northern Nigeria.

This initial shipment will launch a crucial response campaign targeting individuals aged 1 to 29, the most affected demographic. The campaign will begin in Kebbi and Sokoto States and expand to Yobe State as more vaccine doses arrive.

As of April 4, 2025, this meningococcal outbreak has claimed more than 70 lives and affected over 800 individuals across 23 states.

In Africa's 'meningitis belt', seasonal outbreaks are common during the dry season, peaking between March and April due to low humidity and high dust levels.

According to the U.S. CDC, disease rates during epidemics can reach 1% of the local population.

Dr. Muhammad Ali Pate, Nigeria’s Coordinating Minister of Health and Social Welfare, stated in a press release, “The arrival of the Men5CV vaccines is a significant milestone in our fight against the meningitis outbreak."

Gavi, the Vaccine Alliance, funds the global stockpiles of vaccines against cholera, Ebola, meningitis, and yellow fever, accessible to all countries worldwide. 

When visiting Nigeria in 2025, the CDC recommends routine and travel vaccines to prevent polio, measles, yellow fever, and diphtheria infections. 

Apr 4, 2025 • 1:15 pm CDT
US CDC 2025

In Réunion Island, a French department located in the Indian Ocean, an unexpected chikungunya outbreak has overwhelmed the local population.

Since August 2024, about 20,242 chikungunya cases and two related fatalities have been confirmed across the island.

As of April 2, 2025, 14 newborns have been hospitalized following infection with the chikungunya virus. The disease can have serious, even fatal, consequences for newborns and infants.

Due to the acceleration in the number of cases and the spread of outbreaks to almost the entire territory in 2025, the first phase of the free chikungunya vaccination campaign is scheduled to begin on Monday, April 7, 2025. It will be carried out based on a medical prescription by a healthcare provider.

Accoring to ARS Réunion's media statement today, per the recommendations of the High Authority for Health and by decision of the health authorities, this first phase of the IXCHIQ® vaccination campaign primarily targets people aged 65 and over with comorbidities or chronic illnesses and who have not already contracted chikungunya.

The first 40,000 doses of Valneva's single-dose IXCHIQ® vaccine will not be available for pregnant women. Furthermore, this live attenuated vaccine is contraindicated in immunocompromised individuals. 

Since 2023, IXCHIQ® has been approved by the U.S. FDA to treat chikungunya virus infections in adults at increased risk of exposure to the mosquito-transmitted disease. This indication now includes adolescents.

In March 2025, the U.S. CDC issued a Level 2 - Practice Enhanced Precautions Travel Health Advisory regarding Réunion's situation. The CDC wrote, ' Vaccination against chikungunya is recommended for people traveling to a destination with a current chikungunya outbreak.'

As of April 4, 2025, IXCHIQ is commercially offered at travel clinics and pharmacies in various countries, including the United States.

Apr 4, 2025 • 12:03 pm CDT
Google Maps April 4, 2025

The Republic of Trinidad and Tobago Ministry of Health recently announced it is investigating a cluster of Malaria cases in South Trinidad, indicating a potential upsurge in 2025.

As of April 2, 2025, five malaria cases have been confirmed this year.

These five cases are in a well-defined geographic area, and the following field work has been conducted by the Insect Vector Control Division, after the identification of the first case on March 27, 2025:

The Ministry says Trinidad and Tobago, located east of Venezuela, is not endemic for malaria, and as such, most confirmed cases are imported and/or introduced.

Last year, over 200,000 people visited Trinidad and Tobago from a country in North America.

Over the period 2015 to 2024, there were 153 confirmed cases, which is an average of 15 cases per year.

Countries in the Region of the Americas, such as Trinidad and Tobago, reported over 500,000 malaria cases in 2023, a 5% increase from 2022. 

In the United States, the Centers for Disease Control and Prevention (CDC) says millions of residents travel to countries where virus-carrying mosquitoes transmit malaria.

As of week #11 ending March 15, 2025, the CDC confirmed 209 malaria cases in the U.S. this year, with Florida reporting eight travel-related malaria cases.

During 2024, the CDC confirmed 436 measles cases in the U.S.

While two malaria vaccines are available in 2025, neither is offered in the U.S.

 

Apr 3, 2025 • 5:10 am CDT
US CDC April 2025

With warm Caribbean waters and beautiful beaches, The Bahamas is a tourist favorite in 2025. Last year, over 11 million people visited the various islands in The Bahamas.

To ensure visitors departing from the United States are appropriately forewarned about risks 60 miles east of Florida, the State Department recently updated its Level 2: Exercise Increased Caution.

As of March 31, 2025, this Advisory stated that crime can occur anywhere in The Bahamas, with frequent reports in Nassau and Freeport on New Providence and Grand Bahama islands. Additionally, visitors should stay alert in the "Over the Hill" area in Nassau, south of Shirley Street.

And stay alert in vacation rental properties, especially where private security is not present.

Furthermore, boating is not well-regulated, as sexual assaults, injuries, and deaths have occurred. Moreover, never swim alone and beware of jet skis or other watercraft operating close to shore. 

Due to these risks, U.S. government employees are prohibited from using jet skis and personal watercraft rented from independent operators on New Providence and the Paradise Islands.

And be aware of your surroundings and stay alert in public restrooms, as sexual assaults have occurred on and near downtown Nassau beaches.

For local assistance, the U.S. Embassy Nassau is located at 42 Queen Street, Nassau, The Bahamas. You can enroll in the Smart Traveler Enrollment Program to receive digital messages from the Embassy and make locating you in an emergency easier.

From a health risk perspective, the U.S. CDC recommends various routine and travel vaccinations before visiting the Bahamas in 2025. Unlike its Caribbean neighbors, no mosquito-transmitted, vaccine-preventable Chikungunya or Dengue cases were reported in 2025 or 2024.

Travel vaccines are offered at various clinics and pharmacies in the U.S.

Apr 3, 2025 • 4:37 am CDT
Google Maps April 3, 2025

In the Philippines, the Bacolod City Health Office (CHO) recently issued an advisory regarding increasing cases of rotavirus and typhoid.

Typhoid is caused by the bacteria salmonella typhi, which spreads through contaminated food and water or close contact with an infected person.

Data showed that from January to March 22, some 27 cases of typhoid, also known as enteric fever, were reported, compared to only 11 cases during the same period in 2024.

Meanwhile, the CHO reported 74 cases of rotavirus, the most common cause of severe diarrhea among children, during the same period in 2025.

The top risk factor for rotavirus is poor sanitation and hygiene, leading to contamination of food and water.

In its advisory, the CHO said prevention includes washing hands with soap and clean water after using the toilet and before eating, as well as drinking only clear water. If unsure, boil water for three minutes or chlorinate water.

“Go to the nearest barangay health station or center, or consult with your physician if experiencing signs and symptoms of typhoid fever,” Dr. Grace Tan, head of the CHO Environment Sanitation Division, said in a press release on April 2, 2025.

Bacolod City, located on the northwest coast of Negros Island in the Philippines, has become a tourist favorite and was visited by over 800,000 people last year.

The U.S. CDC's Travel Health Advisory for the Philippines recommends vaccination for most travelers, especially those staying with friends or relatives or visiting smaller cities or rural areas.

When departing from the United States in 2025, most travel clinics and pharmacies offer vaccines that prevent both typhoid and rotavirus.

Additionally, the CDC highlights vaccines for chikungunya, dengue, and measles when visiting the Philippines.