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Second Generation Dengue Vaccine Produces Durable T-Cell Protection

Takeda tetravalent dengue vaccine effective in children

October 31, 2024

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As the world confronts dengue fever outbreaks in over 100 countries, many are launching vaccination campaigns to reduce the impact of this mosquito-transmitted disease.

And a Japan-based company is benefiting from increased vaccine sales.

Takeda Pharmaceutical Company Limited today announced that its dengue vaccine QDENGA sales increased 863% in the FY2024 H1, reaching JPY 19.9 billion (~$124 million).

On October 31, 2024, Takeda's quarterly presentation revealed on slide #29, the following insights:

QDENGA is now available in 25 countries, including 18 European countries. Increasing breadth and depth in these markets and further expansion into Malaysia, Israel, and Vietnam in 2024.

Previously, the World Health Organization added QDENGA to its List of Prequalified Vaccines, and the Gavi Board recently approved support for a dengue vaccine program.

In the United States, where QDENGA is unavailable, the Centers for Disease Control and Prevention (CDC) has reported 6,819 travel-related and locally acquired dengue cases in 50 jurisdictions this year, led by California, Florida, New Jersey, New York, and Puerto Rico.

This CDC data indicates an 11% increase compared to 2023, when 6,164 dengue cases were reported.

Vaccine Treats:

Dengue

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Image Caption:

Takeda Pharmaceutical Company Limited October 31, 2024

Live Blog Update Author:

Don Hackett

Location Tags:

Osaka

Vaccine:

QDENGA Dengue Vaccine

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Although the risk for locally acquired malaria in the United States remains very low, its reemergence highlights the importance of vectorborne disease preparedness and response.

On October 24, 2024, the U.S. CDC published MMWR 73(42);946–949 confirmed ten local cases identified in Arkansas, Florida, Maryland, and Texas in 2023.

So far, in 2024, the CDC has confirmed 1,576 travel-related malaria cases, with New York City leading with 220. About 240 people with malaria are reported each year in NYC.

However, the CDC has not reported any local malaria cases this year.

The WHO African Region shoulders the heaviest burden of malaria disease. When visiting malaria-endemic areas, the CDC recommends avoiding mosquito bites and bringing appropriate medications on your trip.

As of October 28, 2024, malaria vaccines are offered in Africa and Europe.

Vaccine Treats:

Malaria

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WHO Malaria case map October 2024

Live Blog Update Author:

Karen McClorey Hackett

Location Tags:

New York City

Vaccine:

R21 / Matrix-M Malaria Vaccine

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Throughout 2024, the world has faced a record number of dengue virus outbreaks. To alert international travelers, the World Health Organization has classified dengue as a grade 3 emergency.

However, the continental United States has remained largely unaffected by this mosquito-borne outbreak.

In the U.S., Florida has reported local dengue cases for several years, while California had only two cases in 2023.

In recent months, Los Angeles has confirmed nine local dengue cases, and San Diego has reported two, bringing the total to eleven cases in California this year.

As reported by the San Diego HHS Agency on October 25, 2024, the second locally acquired dengue case in San Diego County has been confirmed in a Vista resident who became sick and was hospitalized. This person is not associated with the Escondido case.

Nationwide, the U.S. CDC has confirmed 6,494 travel and local-related cases in 50 states this year. Many of these local dengue cases (3,877) have been reported in Puerto Rico, with the San Juan region reporting about 1,400 cases.

And in the Region of the Americas, which includes the U.S., over 12 million cases and 7,289 related deaths in the Americas in 2024.

While Dengue is a vaccine-preventable disease, the U.S. is one of a limited number of countries not offering a vaccine at the end of 2024.

Vaccine Treats:

Dengue

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Google Maps Oct. 27, 2024

Live Blog Update Author:

Don Hackett

Location Tags:

San Diego

Vaccine:

QDENGA Dengue Vaccine

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The U.S. CDC announced an essential update to its Level 2 travel advisory regarding the ongoing Oropouche virus outbreak in Cuba.

As of October 25, 2024, the CDC confirmed multiple cases of Oropouche have recently been reported in U.S. travelers returning from Cuba, indicating there is a detectable risk of infection.

The CDC recently confirmed 91 cases from five states, led by cities along Florida's southeast coast.

The CDC has also issued a Level 1 Travel Health Notice for Oropouche outbreaks in the Region of the Americas, such as in Bolivia, Brazil, Colombia, Dominican Republic, Ecuador, Guyana, and Peru.

From the beginning of the year to early October, 10,275 confirmed cases of Oropouche were reported in nine countries in the Region.

Historically, Oropouche has been confirmed to spread to people following a bite of infected midges (small flies) and mosquitoes.

Recently, Oropouche virus has been found in semen, but it is unknown if it can be spread through sex, says the CDC.

Additionally, pregnant women should reconsider non-essential travel to Cuba since there are concerns about an increase in possible cases of the Oropouche virus being passed from a pregnant person to their fetus associated with fetal deaths and congenital abnormalities.

Since no Ocopouche vaccines are available, the CDC says travelers to Cuba should prevent bug bites during travel to protect themselves from infection.

Vaccine Treats:

Oropouche

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Image Caption:

US CDC October 25, 2024

Live Blog Update Author:

Karen McClorey Hackett

Location Tags:

Cuba

Travel Vaccine Destinations

Travel Vaccine Destinations December 2025

The World Health Organization (WHO) and the U.S. Centers for Disease Control and Prevention (CDC) recommend that all travelers get vaccinated against high-risk diseases before traveling internationally. As of December 2025, the WHO and CDC suggest consulting with a local health practitioner to determine which travel vaccines are recommended for your destination city or country.

The WHO states that some countries require proof of vaccination against yellow fever and polio for travelers entering or exiting the country.

Travel Vaccine Certificates, Passports

Vaccine passports and digital credentials confirm a person has been vaccinated for a particular disease. Various countries require proof of vaccination to obtain a visa for visiting in 2025.

Government Travel Resources

US CDC Travel Health Advisories

U.K. Travel Health Pro

Pan American Health Organization

European Center for Disease Prevention and Control

World Health Organization Disease Outbreak Alerts

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Last Reviewed:

Friday, December 19, 2025 - 11:50

Description:

Disease outbreaks in cities and countries in 2025

Condition:

Chikungunya

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According to the U.S. government, malaria was eliminated from the United States in 1951, and almost all recent cases in the U.S. have been travel-associated.

As of the week ending October 19, 2024 (#42), the U.S. Centers for Disease Control and Prevention confirmed 1,576 travel-related malaria cases this year.

Most malaria cases are confirmed in New York, Florida, California, and Texas.

These cases were associated with travel to 85 countries where malaria remains endemic, such as Africa, and could represent a potential source of Plasmodium infection for locally acquired mosquito-transmitted cases in the U.S.

On October 24, 2024, the CDC reported (73(42);946–949) ten local malaria cases from May to September 2023. In Florida, seven locally acquired malaria cases were reported near Sarasota in 2023.

The CDC says that before traveling internationally to areas where malaria is endemic, travelers should consult with their healthcare provider regarding recommended malaria prevention measures to reduce personal and community risks.

While two malaria vaccines are WHO-recommended, neither are available in the U.S. in 2024.

Vaccine Treats:

Malaria

Image:

Image Caption:

US CDC

Live Blog Update Author:

Karen McClorey Hackett

Location Tags:

Atlanta

Vaccine:

R21 / Matrix-M Malaria Vaccine

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Fact checked by Robert Carlson, MD

Which Vectors Drive Oropouche Fever Transmission in the Americas

Cuba has become Endemic for Oropouche Fever in 2024

October 20, 2024

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0 min read

The U.S. Centers for Disease Control and Prevention (CDC) reissued a Global Travel Health Notice on October 15, 2024, regarding Dengue outbreaks reported in 27 countries in the Americas, Africa/Middle East, and Asia/Pacific Islands.

In the Region of the Americas, over 12,076,930 Dengue cases and 7,171 related deaths have been reported this year.

In the United States, the CDC reported that 50 jurisdictions had reported 6,164 Dengue cases as of October 17, 2024, already exceeding reports from 2023.

For example, the Florida Health Department recently reported over 595 travel-associated and 47 locally acquired Dengue cases throughout the state.

The Texas Department of State Health Services says mosquitoes that transmit Dengue fever are found in Texas, with (78) imported cases reported in 23 counties.

In California, the Los Angeles County Department of Public Health reported eight locally acquired Dengue cases in the San Gabriel Valley this year.

While Dengue is a vaccine-preventable disease, no vaccine is currently available in the U.S.

Vaccine Treats:

Dengue

Image:

Image Caption:

US CDC dengue travel alert map - October 15, 2024

Live Blog Update Author:

Karen McClorey Hackett

Vaccine:

QDENGA (TAK-003) Dengue Vaccine