Travel Vaccine Breaking News

Last year, the World Health Organization (WHO) confirmed the first known case of Western Equine Encephalitis (WEE) in more than two decades in Argentina.

Since then, and until January 9, 2024, 21 human cases in Argentina have been confirmed by the WHO/PAHO.

To alert international travelers to this WEE health risk, the U.S. CDC issued a Level 1 - Practice Usual Precautions, Travel Health Notice on January 12, 2024.

WEE is a rare, mosquito-borne viral disease that affects equines and humans. Most human cases are associated with epidemics in birds or horses.

The CDC says travelers to these regions of Argentina should avoid mosquito bites, which can transmit the Eastern Equine Encephalitis Virus (EEEV).

EEEV transmission is most common in and around freshwater hardwood swamps in the Atlantic and Gulf Coast states and the Great Lakes region in the U.S.

Only about 4-5% of human EEEV infections result in EEE.

In the United States, an average of 11 human cases of EEE are reported annually, according to the CDC. There were 7 EEEV neuroinvasive disease cases in 2023, reported by four states.

From 2012-2021, most cases of EEE have been reported from Massachusetts, Michigan, Florida, Georgia, and North Carolina.

As of 2024, the CDC says no vaccine prevents EEE virus infection.

However, the U.S. Army Medical Research Institute of Infectious Diseases developed a human vaccine for EEE in the mid-1980s, but it has never been approved for public use.

The U.S. government recently invested in a vaccine against western, eastern, and Venezuelan equine encephalitis viruses. 

MVA-BN® WEV has completed Phase 1 clinical development demonstrating potential for broad, and long-term protection, with a Phase 2 study planned for 2024.

The Costa Rica Ministry of Health today announced it confirmed a measles case near the capital city of San Jose.

This new measles patient was detected on January 11, 2024. In 2023, one measles patient was also confirmed.

Given this new measles case, the Costa Rica health authorities conducted all follow-up efforts to address the situation. Currently, this person is in good health.

An active community search for cases in San Josecito de San Rafael de Heredia was conducted on January 18, 2024. As a result of the search, no additional measles cases were found, as most of the people approached had completed vaccination schedules. A total of 408 houses were visited.

After the WHO Region of the Americas was declared measles-free in September 2016, a steady increase in imported measles cases from other WHO Regions and between countries within the Region of the Americas was observed.

For example, several states in the eastern United States have reported measles cases in early 2024.

Last year, the Pan American Health Organization / World Health Organization (PAHO/WHO) urged Member States to continue activities to increase and maintain adequate vaccination coverage against measles, rubella, and mumps (MMR).

Globally, the WHO has reported significant measles outbreaks throughout 2023.

In addition to measles, Costa Rica confronted an expansion of Dengue and Zika cases in 2023.

As the 2024 winter season begins to blanket the United States in snow, the Centers for Disease Control and Prevention today published updated insights regarding influenza vaccinations.

As of January 19, 2024, the CDC reported the percentage of the overall population who received one of the nine approved influenza vaccines was 47.5% (95% confidence interval).

From an age segmentation, the CDC reported the following:

• 46.1-48.8 for children,
• 46.7% (45.8-47.6) for adults 18+,
• 73.0% (70.8-75.2) among adults age 65+.

From an availability perspective, the CDC previously reported that over 155 million flu vaccines (egg, cell, and nasal-based) had been distributed during the 2023-2024 season, which are generally available at most pharmacies in the U.S.

Additionally, the CDC's FluView Updates for Week #2, ending January 13, 2024, stated that after several weeks of increases in key flu indicators through the end of 2023, two weeks of decreasing or stable trends nationally have been noted.

However, seasonal influenza activity remains elevated in most parts of the country.

Furthermore, the CDC is monitoring for a second period of increased influenza activity that often occurs after the winter holidays.

Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator (CARB-X) today announced it is awarding $1.7 million to Syntiron to develop a maternal vaccine that targets Escherichia coli and Klebsiella pneumoniae.

Syntiron's Alloy-EK vaccine leverages iron receptor proteins (IRPs) as vaccine targets. IRPs are highly genetically conserved, which means they are less likely to change since they perform essential functions.

This makes these proteins reliable vaccine targets.

Syntiron developed the Alloy Platform to manufacture and formulate IRP vaccines safely that maintain robust immunity and cover a broad range of bacterial strains.

Neonatal sepsis is a life-threatening response to bloodstream infections that occur in newborns fewer than 28 days old. Due to their immature immune systems, newborns are particularly susceptible to infections.

Since neonatal sepsis progresses rapidly, the risk of death from neonatal sepsis increases by 7.6% every hour a treatment is delayed.

The BARNARDS study estimated that 2.5 million neonates or infants die in the first month of life of sepsis annually, with the most significant burden in low- and middle-income countries. 

"The bacteria targeted by this vaccine are a tremendous burden on public health for babies, children, and adults worldwide," said Lisa Herron-Olson, Ph.D., Managing Director of Syntiron, in a press release on January 18, 2024.

"Pregnant women are at particularly high risk of infection by these same bacteria that can cause neonatal sepsis in newborn babies."

"Preventing these infections by vaccination offers substantial potential health benefits to mothers and babies while reducing the spread of antimicrobial resistance."

Syntiron's innovation with the Alloy Platform leveraged molecular, bioinformatic, and immunological principles to engineer simpler proteins enriched in linear, immunodominant, and highly conserved peptides derived from IRPs.

Founded in 2004, Syntiron is a biotechnology company based in Saint Paul, MN, and has several vaccines in development that target bacterial infections.=

Global spending and demand for medicines will increase over the next five years to approximately $2.3 trillion by 2028 as more patients get access to new and better medicines, according to the IQVIA Institute.

On January 17, 2024, IQVIA published a new report for Human Data Science titled “The Global Use of Medicines 2024 – Outlook through 2028.”

This updated projection raises the growth outlook by 2% despite lower expectations for COVID-19 vaccines and therapeutics.

“The continued growth in spending is driven by an increase in the volume of medicines (vaccines), which reflects that more patients globally are getting access to novel medicines with better clinical outcomes,” said Murray Aitken, SVP and executive director of the IQVIA Institute for Human Data Science, in a press release.

Highlights of this report include, but are not limited to, the following:

Global use of medicines grew by 14% over the past five years, and a further 12% increase is expected through 2028, bringing annual use to 3.8 trillion defined daily doses.

This increase in growth outlook is driven by more patients getting treated with better medicines, especially in immunology, endocrinology, and oncology.

Medicine use in Latin America and Asia will grow faster than in other regions over the next five years.

Using estimated net prices, the updated outlook for the U.S. market is being raised to 2-5% CAGR through 2028, reflecting higher recent growth and expected further increased patient use of higher-value therapies.

IQVIA (NYSE: IQV) is a leading global provider of advanced analytics, technology solutions, and clinical research services to the life sciences industry.

The Philadelphia Health Department reported another new case of measles, the ninth confirmed measles case in 2024.

Today’s (Jan. 16, 2024) case is the 5th measles case associated with the previously reported daycare outbreak.

According to the U.S. Centers for Disease Control and Prevention (CDC), most measles outbreaks in the United States are related to unvaccinated international travelers.

Since measles is a vaccine-preventable disease, the Health Department is coordinating several vaccination opportunities to ensure that children and adults who need the measles, mumps, and rubella (MMR) vaccine can be vaccinated for free in their community.

People seeking MMR vaccination do not need any identification; a piece of mail with an address on it will qualify them as a Philadelphia resident, and insurance is not required to be vaccinated.

In addition to the measles outbreak in Philadelphia, cases have recently been reported in New Jersey, Delaware, and Virginia.

On the West Coast, six measles cases were recently confirmed in Clark and Wahkiakum counties in Washington in January 2024.

Globally, the CDC identified 47 countries with recent measles outbreaks led by Yemen and India.

In the U.S., measles vaccination services are generally offered at clinics and pharmacies.

The Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator (CARB-X) today announced it is awarding $633k to Intravacc to support the development of the Avacc® 11 vaccine candidate that prevents Neisseria gonorrhoeae bacterial infections.

This CARB-X award supports the development of Intravacc's meningococcal outer membrane vesicle (OMV) vaccine that carries several important gonococcal antigens to prevent Neisseria gonorrhoeae (gonococci) infections.

Through the tailored gonococcal antigens on the surface of the meningococcal OMV, Intravacc anticipates a significant enhancement in the vaccine candidate's efficacy against gonorrhea.

"Drug-resistant strains of Neisseria gonorrhoeae have evaded all but one existing antibiotic (ceftriaxone)," said Erin Duffy, PhD, R&D Chief of CARB-X, in a press release on January 16, 2024. 

"Vaccines are powerful tools in the prevention of bacterial infections."

"With an appropriate vaccination strategy, Intravacc's vaccine project, if successful, could prevent the disease and significantly curb the spread of resistant bacteria across the globe."

The WHO Global Health Sector Strategy on Sexually Transmitted Infections (STI) has set goals for reducing gonorrhea incidence by vaccination by 90% by 2030. Gonorrhea is the world's second most reported STI, impacting about 82 million adults annually.

As of 2024, the U.S. FDA has not approved a gonorrhea vaccine.

However, a Research Letter published by the JAMA Network Infectious Diseases on August 31, 2023, concluded that the Outer Membrane Vesicles-based meningococcal group B vaccine was 47% (95% CI, 13%-68%) effective in preventing gonorrhea in young adults.

On November 10, 2023, the U.K.'s Joint Committee on Vaccination and Immunisation agreed that a targeted vaccination program should be initiated using the 4CMenB (Bexsero®) vaccine for the prevention of gonorrhea in those who are at most significant risk of infection. 

Intravacc is a global contract development and manufacturing organization at the Utrecht Science Park Bilthoven in the Netherlands. Intravacc is developing vaccines that target a range of diseases.