16th Ebola Outbreak in the Democratic Republic of the Congo Continues

The 16th Ebola virus disease (EVD) outbreak in the Democratic Republic of the Congo (DRC) continues as of October 2025; however, there are signs of a notable decline in transmission.

As of the end of September 2025, a total of 64 cases (53 confirmed and 11 probable), including 42 deaths (31 confirmed, 11 probable), have been reported from Bulape Health Zone, Kasai Province, Democratic Republic of the Congo.

Since the World Health Organization (WHO) Situation Report #2, a total of seven new EVD cases have been reported. The latest cases were detected across three areas within Bulape Health Zone, namely, Bulape, Mpianga, and Dikolo.

During the same reporting period, seven deaths occurred among newly identified and previously hospitalized cases.

The overall case fatality ratio (CFR) during this, the 16th EVD outbreak in the DRC, is 65.6% (64 cases, 42 deaths).

The U.S. CDC recently stated that, although not commercially available in the USA, an FDA-approved vaccine exists for the prevention of Ebola virus (species Orthoebolavirus zairense). It is currently available to select individuals in specific occupations (e.g., outbreak responders).

Contact your healthcare provider to discuss eligibility and access to the Ebola vaccine (Ervebo), as recommended by the CDC.

Additionally, the CDC recommends vaccinations for measles, polio, and several routine diseases before visiting the DRC in 2025.