Chicago's Mpox Outbreak Continues

While the United States has witnessed a reduction in Mpox cases in 2025, the city of Chicago's recent spike in cases has not abated.

According to the Chicago Department of Public Health (CDPH), from June to September 30, 2025, 104 cases of Mpox have been reported. Those are more cases than were reported over the same time period in 2023 (40) and 2024 (53) combined.

The median age of those diagnosed with the sexually transmitted Mpox virus over the past four months is 34, of whom most are men.

The CDPH data underscore the fact that this is a critical time for the mpox vaccination effort to limit new Mpox cases in Chicago, IL.

As of October 4, 2025, the U.S. Centers for Disease Control and Prevention (CDC) has not issued a Travel Health Notice regarding this Mpox outbreak.

CDPH is co-sponsoring several mpox vaccination events throughout October 2025.

Vaccination is especially encouraged for sexually active gay and bisexual men, who are most at risk.

The CDC-recommended Mpox vaccine (JYNNEOS®) is available at CDPH Sexual Health Clinics and throughout the USA.

Globally, the World Health Organization (WHO) recently published its 58th situation report on the multi-country outbreak of mpox. As of September 19, 2025, the WHO reported that 59 countries confirmed a total of 3,780 cases, including 15 related fatalities. Both clades of the monkeypox virus continue to circulate in various countries.