Travel Vaccine Breaking News

Travel vaccine breaking news brought to you by Vax Before Travel.

Jan 20, 2025 • 9:18 am CST
WHO

The Coalition for Epidemic Preparedness Innovations (CEPI) today announced that Afrigen Biologics aims to develop the first-ever mRNA-based vaccine against Rift Valley fever, supported by a new $6.2 million grant.

Confirmed on January 20, 2025, the researchers will work with the International Vaccine Institute to progress the new vaccine candidate through preclinical development and into Phase I clinical testing in people in either South Africa or another outbreak-affected country on the continent.

If clinical trials are successful, this vaccine could offer a critical new, locally produced tool to help combat this potentially deadly illness, which poses significant risks to human health and livestock.

Dr Richard Hatchett, CEO of CEPI, commented in a press release, “This new research will further strengthen the continent’s future preparedness and response capabilities, thereby enhancing Africa’s vaccine sovereignty and health security.”

First identified in Kenya’s Rift Valley in the 1930s, Rift Valley fever usually occurs in people following direct contact with infected animals, like sheep, goats, and cattle, or bites from infected mosquitoes, says the U.S. CDC.

The disease has also expanded in range in recent years with outbreaks in the Middle East and Indian Ocean islands, hence the need for new Rift Valley fever (RVF) vaccines.

Fortunately, a case of RVF virus spreading from person to person has never been reported.

While the majority of people infected experience mild disease, around 1-2% of those infected can develop the severe hemorrhagic form, which can cause blindness, convulsions, encephalitis, and bleeding and has mortality rates of around 50%. 

Although vaccines against RVF have been registered for animals, no vaccines are available or licensed for human use. Therefore, the World Health Organization and the African Centres for Disease Control and Prevention recognize it as a priority target disease. 

As of January 4, 2025, the CDC did not report any Rift Valley fever cases in 2024 or 2025.

Jan 19, 2025 • 12:47 pm CST
US CDC 2025

The Houston Health Department (HHD) recently announced two measles cases associated with international travel. Both adults reside in the same Houston, Texas household and have unknown vaccination statuses.

HHD stated these are the first reported measles cases in Houston since 2018.

Texas experienced a travel-related measles outbreak in 2019, which led to 23 cases.

Measles was officially eliminated from the United States in 2000. However, as of late December 2024, 32 U.S. jurisdictions, led by Illinois and Minnesota, had reported 284 cases, many of which were travel-related.

Internationally, the U.S. Centers for Disease Control and Prevention (CDC) maintains a global Watch-Level 1 Travel Health Notice identifying measles outbreaks in 59 countries last year.

As of January 19, 2025, HHD and the CDC say the most effective way to prevent measles virus infections is to get the measles, mumps, and rubella (MMR) vaccine. Measles vaccination services are offered at most travel clinics and pharmacies. 

Jan 18, 2025 • 11:25 am CST
Google Maps 2025

The Centers for Disease Control and Prevention (CDC) has detected an increase in extensively drug-resistant Shigella infections in the United States over the past few years.

As of January 11, 2025, the U.S. CDC confirmed 296 Shigellosis cases have already been reported in 2025, led by New York (53) and Florida (42).

Last year, the CDC confirmed 20,621 Shigella cases nationwide, led by California (4,365) and New York (2,990).

In Northern Nevada, the Public Health (NNPH) agency identified a Shigellosis outbreak in Reno / Washoe County after a reported influx of new cases and hospitalizations. About 14 cases and nine hospitalizations were reported, although the number of cases is expected to be much higher.

However, there is a low risk of transmission to the general public in 2025.

Shigellosis is an intestinal infection that causes diarrhea, fever, and stomach pain. Shigellosis can be spread by coming into contact with the poop of an infected person, eating or drinking contaminated food or water, or through sexual contact.

According to the CDC, Shigellosis can be challenging to treat, and prevention is critical to reducing the spread of the infection.

As of January 18, 2025, the U.S. FDA has not approved a preventive vaccine. However, a tetravalent bioconjugate vaccine candidate has progressed into phase 2 clinical research.

Jan 17, 2025 • 1:24 pm CST
US CDC Ethiopia Jan. 17, 2025

Despite spending $4 billion annually, the number of malaria cases and deaths has not significantly changed over the past decade, especially in Africa. Last year, the WHO's African Region reported the broadest malaria outbreak burden.

Based on today's U.S. Centers for Disease Control and Prevention (CDC) Travel Health Advisory, health agencies are not optimistic about seeing any improvement in this trend by 2025.

Today, the CDC confirmed an ongoing malaria outbreak in the Federal Democratic Republic of Ethiopia, affecting all 14 country regions. More than 8.4 million malaria cases were reported, the highest number of cases ever reported within a year.

To bolster Ethiopia’s fight against malaria, the United States Government, through the U.S. Agency for International Development, donated 175 computer terminals to the Ethiopian Public Health Institute on January 15, 2025.

Additional U.S. support includes over $27.5 million of antiretroviral supplies, early infant diagnostics, quality assessment panels, lab equipment, and more.

Malaria is a disease caused by a parasite that spreads to humans through the bite of infected mosquitoes, commonly found in Africa.

If you plan to travel to Ethiopia in 2025, the CDC recommends speaking with a travel health expert about which antimalarial drug is best for you. And seek medical care immediately if you develop fever, chills, sweats, headache, vomiting, or body aches during or after travel to Ethiopia. 

In 2024, numerous international travelers brought malaria back with them.

As of the week ending November 23, 2024, the CDC confirmed 1,772 malaria cases, mostly among international travelers arriving in New York City (232), Texas, Miami, Florida, and Los Angeles, California. 

While malaria vaccines are available in Africa, they are not FDA-approved in the U.S. and remain unavailable in the U.S.

Furthermore, innovative vaccine candidates, such as the RH5.1/Matrix-M malaria vaccine, are proceeding in late-stage clinical trials. Developed at the University of Oxford, this vaccine targets blood-stage malaria, unlike previously approved vaccines that target the pre-erythrocyte stage. 

Jan 16, 2025 • 1:01 pm CST
by Alessandro Danchini

The U.S. Centers for Disease Control and Prevention (CDC) today announced details of a gastrointestinal illness (GI) outbreak on the Silversea Cruises ship Silver Ray.

On January 16, 2025, the CDC reported that 38 guests and five crew members were ill among the 681 people onboard Voyage RA250104016. 

This data represents 6.6% of all people onboard the Silver Ray.

The main symptoms of the patients were diarrhea and abdominal cramps. The CDC reported that the causative agent remains unknown.

This incident is the second GI outbreak aboard a cruise ship in 2025.

Last year, the CDC confirmed 18 outbreaks aboard cruise ships, with norovirus as the primary disease agent.

'Norovirus is often a cause of GI outbreaks on cruise ships, but we don't always know the cause of the outbreak when investigations begin, writes the CDC.

A study published in January 2025 identified cruise ship dining areas as priorities for preventing disease outbreaks. However, the probability of airborne infection in a speaking normal condition is low (<3 %).

As of January 2025, norovirus vaccine candidates are conducting clinical research, but none have been U.S. FDA-approved.

For a potential treatment, Travelan®, an orally administered passive immunotherapy, prophylactically reduces the likelihood of contracting travelers' diarrhea. In the U.S., Travelan is sold as a dietary supplement for digestive tract protection.

Note: This article was updated on Jan. 17, 2025, to include a reference link.

Jan 16, 2025 • 10:33 am CST
from Pixabay 2025

The Pan American Health Organization (PAHO), the Government of Argentina, and others today announced a joint effort to facilitate local production and regional access to the 20-valent pneumococcal conjugate vaccine (PCV20).

This vaccine is expected to further protect against severe diseases caused by Streptococcus pneumonia  (pneumococcus), responsible for pneumonia, meningitis, and other serious infections, including those linked to antibiotic-resistant strains.

In 2021, 3,345 children under the age of 5 died due to pneumonia and meningitis caused by pneumococcus in Latin America and the Caribbean.

Through this initiative, not only will Argentina benefit from local production of the PCV20 (PREVNAR 20®), but countries across the Region of the Americas will be able to access vaccine doses through PAHO’s Regional Revolving Funds, ensuring more rapid vaccine rollout at competitive prices.

The PCV20 vaccine will be available in Latin America and the Caribbean starting in early 2025. The first doses produced in Argentina are estimated to be available by 2026.

“PAHO is committed to boosting regional production of sustainable, innovative technologies by strengthening existing capacities and our regional purchasing mechanism, the Revolving Fund for Access to Vaccines,” said PAHO Director Jarbas Barbosa in a press release on January 15, 2025.

“This collaboration reflects our dedication to ensuring equitable access to safe, effective vaccines that prevent severe diseases and save lives,” he added.

Jan 16, 2025 • 3:13 am CST
Google Maps 2025

According to local media in India, medical experts have not determined the cause of death of 14 people in the Badhal village in the border district of Rajouri.

Since early December 2024, fourteen of 38 affected persons have died due to a 'mysterious disease.'

The Star reported on January 15, 2025, that experts from the PGIMER Chandigarh, Council of Scientific & Industrial Research, National Institute of Virology, National Centre for Disease Control, Defence Research and Development, and other organizations have so far been unable to detect the cause of the affected persons belonging to three interlinked families.

The Rajouri district is in the remote Jammu division of the Indian union territory of Jammu and Kashmir.

This is a developing story.

Jan 15, 2025 • 12:37 pm CST
by Dimitris Vetsikas

According to media reports, the Republic of Cyprus cruise ship arrivals at the port of Limassol for 2024 were not fully realized due to the current geopolitical situation.

CBN reported last year that the management company of the passenger terminal at the port of Limassol, the principal seaport of the island, emphasized that it remains optimistic about a strong recovery in 2025 and 2026 in the Eastern Mediterranean region.

Similar to this optimism, the U.S. Department of State updated its Travel Advisory for Cyprus, remaining at Level 1: Exercise Normal Precautions as of January 13, 2025.

However, when visiting Cyprus, do not attempt to enter the United Nations buffer zone at any place other than a designated crossing point. The U.S. Embassy in Nicosia can only assist U.S. citizens in this area to a limited extent.

If you travel to Cyprus, the State Department suggests enrolling in the Smart Traveler Enrollment Program to receive security messages and to help locate you in an emergency.

Since 1974, the southern part of Cyprus has been controlled by the internationally recognized Government of the Republic of Cyprus. The northern part of Cyprus proclaimed itself the “Turkish Republic of Northern Cyprus” in 1983.

From a health perspective, the U.S. CDC says visitors should be aware of current health issues in Cyprus, such as measles.

And speak with a vaccine expert at least one month before departure to discuss travel vaccine options.

Jan 15, 2025 • 12:02 pm CST
from Pixabay 2025

Immuron Limited today announced that it had submitted the Clinical Study Report to the U.S. Food and Drug Administration (FDA) for the recently completed Phase 2 study with Travelan® (IMM-124E) and will soon request an end-of-Phase 2 meeting, which is a pre-cursor to proceeding to Phase 3.

As of January 14, 2025, the company wrote, 'This study data implies that Travelan® appears to aid in the reduction and clearance over time of pathological ETEC bacteria, by shortening the recovery period after Enterotoxigenic Escherichia Coli (ETEC) challenge.'

In the phase 2 study, statistically significant lower levels of IgA and IgG were observed for the subjects who received Travelan® compared to those who received the placebo, which may also reflect levels of exposure to ETEC antigen.

Travelan antibodies target and bind to ETEC antigen in the gastrointestinal tract, block LPS epitopes and therefore reduce antigen exposure, resulting in lower overall IgA and IgG antibody titers.

Clinical data also demonstrated a statistically significant reduction in colony-forming units in the stools of subjects who received Travelan® (p =0.0121), measured 48 hours post-challenge. This indicates faster clearance of the challenge strain from the GI tract.

Travelan® is an orally administered passive immunotherapy that prophylactically reduces the likelihood of contracting travelers’ diarrhea (TD). This digestive tract disorder is commonly caused by pathogenic bacteria and the toxins they produce.

TD continues to be the most frequent health problem among travelers to destinations in lower—and middle-income regions. Between 8% and 50% of travelers develop diarrhea, and the incidence depends on the country visited. However, travelers can have multiple episodes of diarrhea during one trip.

TD is different from a norovirus infection caused by nonenveloped, single-stranded RNA viruses. Norovirus causes viral gastroenteritis, which is sometimes referred to as stomach flu.

According to the U.S. CDC, norovirus is a commonly reported cause of diarrhea among travelers in confined spaces, such as on cruise ships.

As of January 2025, there are no norovirus vaccines available.

In the U.S., Travelan® is sold as a dietary supplement for digestive tract protection.

 

Jan 15, 2025 • 9:49 am CST
Maps 2025

Quebec's Ministère de l'Environnement, de la Lutte contre les changements climatiques, de la Faune et des Parcs recently advised the public that a raccoon infected with the rabies virus was found dead in Saint-Armand, in the Estrie region, on December 17, 2024.

As of January 15, 2025, this is the first case of raccoon rabies in Québec since 2015.

The animal was found about 1.4 kilometers from where a case had been discovered near the Québec border, in the municipality of Highgate, Vermont.

In a media release, the government stated that 'it should be noted that over the past year, several cases of raccoon rabies have been identified in northern Vermont.

The evolution of the situation is being closely monitored by the Gouvernement du Québec, which continues its close cooperation with American authorities to optimize control and surveillance efforts on both sides of the border. 

Raccoon, skunk, and fox vaccination interventions are planned for 2025. An analysis is underway to determine the best intervention strategy, which will be tailored to the situation. 

In the United States, most rabies infections are related to infected bat bites.

In December 2024, the Kentucky and California health departments reported people had died after being infected with the rabies virus.

Furthermore, rabies vaccines for people are offered at various clinics and travel pharmacies in 2025.

Jan 15, 2025 • 5:37 am CST
Google Maps - Jan. 15, 2025

The World Health Organization (WHO) recently informed its Member States of a suspected Marburg Virus Disease (MVD) outbreak in the Kagera region of the United Republic of Tanzania.

On January 13, 2025, the WHO wrote that the risk of this suspected MVD outbreak is assessed as high at the national level due to several concerning factors.

The regional risk is also considered high due to the Kagera region's strategic location as a transit hub, with significant cross-border movement of the population to Rwanda, Uganda, Burundi, and the Democratic Republic of the Congo. 

As of early January 2025, nine suspected cases were reported, including eight deaths (case fatality ratio of 89%) across two districts – Biharamulo and Muleba.

Close contacts, including healthcare workers, are reported to have been identified and under follow-up in both districts. Human-to-human transmission of Marburg virus is primarily associated with direct contact with the blood and/or other bodily fluids of infected people.

The Bukoba district in the Kagera region experienced its first MVD outbreak in March 2023, and zoonotic reservoirs, such as fruit bats, remain endemic to the area. The outbreak in 2023 lasted for nearly two months, with nine cases and six deaths. 

Since 1967, MVD outbreaks have been confirmed in various countries.

The WHO advises against travel and trade restrictions with Tanzania based on the current risk assessment.

As of January 15, 2025, the U.S. CDC issued a Level 1 - Practice Usual Precautions, Travel Health Advisory for visiting Tanzania. Previously, the CDC included Tanzania in its current global polio Travel Health Advisory.

Furthermore, no U.S. FDA-approved Marburg vaccines exist, but candidates are conducting clinical trials.

Jan 14, 2025 • 9:32 am CST
Micron's “peel & stick” microarray technology 2025

Today, Micron Biomedical announced that the U.S. Department of Health and Human Services (HHS) awarded the company $2 million to continue its work on broadly protecting avian and seasonal flu vaccines.

The company won the Biomedical Advanced Research and Development Authority (BARDA) Patch Forward competition. The $2 million award will advance Micron’s work to co-develop needle-free versions of broadly protecting influenza vaccines with Zipcode Bio, a biotechnology company focusing on next-generation RNA medicines.

“Making all vaccines, including influenza vaccines, more broadly protecting and more accessible has the potential to save lives globally, and we are thrilled to be recognized by the HHS, BARDA, as one of the most important vaccine innovations rethinking how vaccines will be administered,” said Steven Damon, CEO of Micron Biomedical, in a press release on January 14, 2025.

“We are thrilled to continue our collaboration with Zipcode Bio and accelerate efforts to make the dream of needle-free, broadly protecting influenza vaccines a reality.”

Micron’s technology uses a dissolvable microarray “button” applied to the skin. The button painlessly delivers a vaccine or therapeutic directly into the uppermost dermal layers when pushed. The button can be self-administered or administered by a caregiver or parent. 

Micron previously announced that it had received a $7.5 million grant from the Bill & Melinda Gates Foundation, for a total of $43 million in support from the organization.

Over the past decade, the World Health Organization (WHO) and the National Academy of Sciences have written, A future influenza pandemic is inevitable.... are we ready?

From January 2003 to November 2023, the WHO reported 246 cases of human infection with the avian influenza A(H5N1) virus from four WHO Western Pacific Region countries. Of these, 138 were fatal, resulting in a case fatality rate (CFR) of 56%.

According to the U.S. Centers for Disease Control and Prevention and the Department of Agriculture, mammalian infections with the highly pathogenic avian influenza virus will be a global concern in 2025.

As of early 2025, the U.S. government has invested in developing avian influenza vaccine candidates.

Jan 14, 2025 • 4:41 am CST
by Pete Linforth

Emergent BioSolutions Inc. today announced that the Biomedical Advanced Research and Development Authority (BARDA) executed a contract modification for the second option period, valued at approximately $16.7 million.

This option is part of Emergent's existing 10-year contract with BARDA for the advanced development and procurement of Ebanga™, which has a maximum value of $704 million.

This modification will validate the drug product process and analytical testing and ensure long-term stability for Ebanga, which is indicated for treating infection caused by the Zaire Ebola virus.

Ebanga (ansuvimab-zykl) is a Zaire ebolavirus glycoprotein-directed human monoclonal antibody indicated for treating infection caused by Zaire ebolavirus in adult and pediatric patients.

As of 2025, the U.S. Department of Homeland Security has determined that Ebolavirus disease (EVD) threatens national health security. To augment the government's response capability, BARDA is pursuing the advanced development, licensure, and procurement of therapeutics that can be deployed in EVD outbreaks.

"We are delighted our continued collaboration with BARDA is advancing Ebanga development toward supplying treatment and ensuring communities are prepared against Ebola (outbreaks)," said Simon Lowry, M.D., chief medical officer, head of research and development, Emergent, in a press release on January 13, 2025.

"Ebola is a devastating infectious illness with limited treatment options."

Ebanga is not a preventive vaccine.

As of early 2025, Merck's U.S. FDA-approved Ervebo® (rVSV-ZEBOV) vaccine was licensed in the U.S., the U.K., the European Union, Canada, and various countries. Recently, Sierra Leone became the first country in Africa to launch a preventive Ebola vaccination campaign targeting health workers.

Ervebo is not commercially available in the U.S.

Orthoebolavirus zairense (EVD) is severe and often fatal, with case fatality rates ranging from 25% to 90%, and is transmitted via bodily fluids, zoonotic transmission, or contact with contaminated surfaces. 

According to the World Health Organization, more than 30 EVD outbreaks have been reported. The initial Zaire Ebolavirus case was confirmed in 1976 in a village near the Ebola River.

As of 2025, no active U.S. CDC Travel Health Notice is focused on Ebola outbreaks in Africa.

Jan 13, 2025 • 1:16 pm CST
Walgreens Flu Index 2025

The Walgreens Flu Index® recently highlighted the top 10 areas in the United States with influenza activity.

As of January 4, 2025, the cities were primarily located in the south-central U.S.

  1. Harlingen-Weslaco-Brownsville-McAllen, Texas,
  2. Knoxville, Tenn.,
  3. Montgomery-Selma, Ala.
  4. New Orleans, La.,
  5. Jackson, Miss.,
  6. Beaumont-Port Arthur, Texas,
  7. Huntsville-Decatur (Florence), Ala.,
  8. Nashville, Tenn.,
  9. Birmingham (Anniston and Tuscaloosa), Ala.
  10. El Paso, Texas (Las Cruces).

The Walgreens Flu Index provides state—and market-specific information regarding flu activity. It is compiled using retail prescription data for antiviral medications used to treat influenza at Walgreens's thousands of pharmacies nationwide, including Puerto Rico.

The Flu Index is not intended to illustrate flu activity levels or severity, but it complements the weekly data posted by the U.S. CDC. It is an interactive tool that allows users to search by market or state to see where their geographic area ranks for flu activity in any given week. 

In 2024, over 92 million flu shots were distributed in the U.S. As of January 13, 2025, various vaccine types remain available at most community pharmacies. They are recommended for most children and adults, and booster doses are often suggested for certain people.

Jan 13, 2025 • 12:16 pm CST
WHO - Jan. 13, 2025

According to the World Health Organization (WHO), the clade Ib monkeypox virus (MPXV) outbreak began in September 2023 and continues predominantly in the Democratic Republic of the Congo, Burundi, and Uganda, with travel-related cases identified in other countries.

In Africa, from January 2024 to January 5, 2025, 14,700 confirmed mpox cases, including 66 deaths (CFR – 0.4%), have been reported by 20 countries. And continues to meet the WHO criteria for a public health emergency of international concern.

As of January 14, 2025, the ECDC reported eleven individuals with MPXV clade I in the EU/EEA since August 2024.

One case was reported by Sweden in August 2024, seven by Germany (one in October, five in December 2024, and one in January 2025), two cases by Belgium in December 2024, and one case by France in January 2025

The WHO says two virus types cause mpox, clade I and II. Both types spread the same way and can be prevented using the same methods, including vaccination.

Most mpox outbreaks in other areas are due to clade IIb MPXV, a continuation of the multi-country outbreak that began in May 2022.

In the United States, the CDC assessed on January 10, 2025, the overall risk to the population(s) posed by the clade I mpox outbreak as low. And clade II mpox is still circulating at low levels.

Various mpox vaccines continue to be available in impacted countries.

Note: Updated on Jan. 14, 2025, to include ECDC data.