Travel Vaccine Breaking News

Travel vaccine breaking news brought to you by Vax Before Travel.

May 1, 2023 • 7:37 pm CDT
U.S government

The U.S. Administration today announced it would end COVID-19 vaccine requirements for international air travelers at the end of the day on May 11, 2023, the same day that the COVID-19 public health emergency comes to an end in the U.S.

Additionally, as of May 1, 2023, government agencies will start the process of ending their vaccination requirements for certain noncitizens at land borders.

Further details related to ending these requirements will be provided in the coming days.

Previously, the Centers for Disease Control and Prevention announced changes to its travel COVID-19 vaccination policy on April 27, 2023.

May 1, 2023 • 4:38 pm CDT
Indonesia Ministry of Health measles cases April 28, 2023

The World Health Organization (WHO) recently reported, based on the current data and available information from the Indonesia Ministry of Health, the overall risk of measles at the national level is assessed as high.

And the WHO reconfirmed measles is endemic in Indonesia and is an ongoing risk around the world.

On April 28, 2023, the WHO reported a total of 2,161 measles cases had been reported across 18 of 38 provinces in Indonesia, primarily from the provinces of West Java (796 cases) and Central Papua (770 cases) from January thru April 3, 2023.

In 2022, a total of 4,845 laboratory-confirmed measles cases and six deaths were reported across 32 of the 38 provinces. 

To alert international visitors, the U.S. CDC issued a Watch - Level 1, Practice Usual Precautions regarding the global measles outbreak, which included Indonesia.

Recently, American Samoa's government declared a measles outbreak.

Measles is caused by a highly contagious virus that spreads through the air by direct contact with infectious droplets or by airborne spread when an infected person breathes, coughs, or sneezes. The measles virus can live for up to two hours in airspace after an infected person leaves an area.

Furthermore, the CDC says that measles can be severe in all age groups and can lead to serious complications, such as pneumonia.

And all international travelers, including infants and children, should be fully vaccinated against measles.

Measles vaccines are generally available at clinics and community pharmacies in the U.S.

May 1, 2023 • 3:48 pm CDT
by Max from Pixabay

The peer-review journal Vaccine recently announced a post hoc analysis of the PREVENT-19 phase 3, randomized, placebo-controlled clinical trial of Maryland-based Novavax NVX-CoV2373 vaccine efficacy against hospitalization.

Published on April 29, 2023, the Novavax COVID-19 vaccine arm showed no instances of hospitalization among participants in both the per-protocol efficacy analysis and expanded efficacy analysis populations.

As a result, the vaccine demonstrated a 100% efficacy rate against hospitalization in both groups.

Compared to the per-protocol efficacy analysis population of the PREVENT-19 study, the percentage of total participants with any coexisting conditions (47.3%) or with a medical history of obesity (37.2%) was higher among hospitalized participants from the expanded efficacy analysis population (100%, and 91%, respectively), though the latter only represents a small fraction of the former's sample size.

In summary, these researchers wrote, 'These additional data from the PREVENT-19 trial provide relevant public health information concerning the attributes of NVX-CoV2373 (Nuvaxovid™, CovoVax™).'

Disclosures: The authors declare the financial interests/personal relationships that may be considered potential competing interests.

Note: A separate phase 3 randomized clinical trial published in The JAMA Network on April 26, 2023, found Novavax vaccine efficacy was 79.5%, and reactogenicity was mostly mild to moderate and transient; no safety concerns were identified in 2,247 adolescents.

May 1, 2023 • 8:44 am CDT
from Pixabay

Despite the U.S. government's plan to end the public health emergency in May 2023, the National Council on Aging (NCOA) today announced it is distributing about $50 million in Department of Health and Human Services (HHS) grants to improve COVID-19 vaccine access and education.

"Those living at home are less likely to have access to the pharmacy," commented Josh Hodges, Chief Customer Officer at NCOA, as McKnight's Home Care Daily Pulse reported on May 1, 2023.

"They're less likely to be able to interact with their community as a whole, so bringing the vaccine into the home is part of what many of our organizations are doing."

"It's not only important for the individual themselves, but the caregivers, the family members, and those surrounding the older adult," added Hodges.

With $50 million in federal funding from the HHS' U.S. Administration for Community Living, the largest grant in its history reported NCOA.

Previously, LeadingAge confirmed on April 17, 2023, it would distribute $270,000 in grants among 20 member organizations to boost vaccinations. 

LeadingAge's partnership with HHS' We Can Do This campaign is the latest pandemic-related collaboration between the two organizations. 

Note: Pharmacies in the U.S. have distributed over 50% of all COVID-19 vaccines in 2023.

May 1, 2023 • 8:08 am CDT
U.S. CDC American Samoa may May 1, 2023

The American Samoa Department of Health's latest Situation Report confirmed additional measles cases. As of April 30, 2023, the health department reported two confirmed measles cases and 52 probable.

American Samoa declared a public health emergency on April 24, 2023.

However, the U.S. CDC has not issued a related measles alert as of May 1, 2023. The CDC did issued a Global Measles Alert on April 6, 2023.

Measles is among the most contagious viral diseases known. Infected people are usually infectious from 4 days before until four days after rash onset. Therefore, the CDC suggests infants and unvaccinated adults traveling internationally should get one dose of a measles vaccine before traveling.

American Samoa is an unincorporated territory of the U.S. located in the South Pacific Ocean.

Apr 30, 2023 • 6:18 pm CDT
by Guille NeT

According to a non-peer-reviewed study, a strain of avian influenza H5N1 (bird flu) has been found to transmit between ferrets effectively.

Published by Biological Sciences on April 21, 2023, these researchers determined that uncharacterized genetic signatures may be important determinants of mammalian adaptation, and these Highly Pathogenic Avian Influenzas (HAPI) pathogenicity clade 2.3.4.4 viruses.

Clade 2.3.4.4b H5N1 viruses were first isolated from poultry and wild birds in Canada in December 2021. Since then, millions of birds have died worldwide.

And various mammals, such as bears, cats, dogs, seals, and others, have died from HAPI infections.

This study encouraged 'ongoing surveillance of circulating HPAI A(H5N1) viruses across species, including humans, should be a top priority to promptly identify viruses that may have pandemic or outbreak potential in mammals.'

While few human cases of infection with clade 2.3.4.4b viruses were reported as of April 30, 2023, the potential for spillover, particularly of viruses harboring mammalian adaptation signatures, remains a critical concern.

The U.S. CDC says the annual flu shot is not designed to protect people from bird flu viruses.

However, the U.S. government has already approved one vaccine (Audenz™) for this type of bird flu.

Apr 30, 2023 • 4:43 pm CDT
UT Health San Antonio April 2023

Blue Water Vaccines (VWV) Inc. recently announced the signing of a Sponsored Research Agreement with The University of Texas Health Science Center at San Antonio to fund a non-human primate ("NHP") study to evaluate the efficacy of BWV-401, a live attenuated, orally delivered Chlamydia vaccine candidate.

In this new effort, BWV will fund an NHP study to evaluate the efficacy of BWV-401 further and provide additional support for development towards human clinical trials.

In this upcoming study, NHPs will be vaccinated with BWV-401 and subsequently challenged against Chlamydia to validate the hypothesis that, along with being safe, this vaccine, when delivered orally, can elicit an effective immune response in the genital tract and can protect against Chlamydia infection.

BWV-401 utilizes a modified strain of Chlamydia to colonize in the gastrointestinal tract and has produced transmucosal protection against genital tract Chlamydia infection in mouse models without altering the gut microbiota.

"We are thrilled to initiate this study with our partners at UT Health Science Center San Antonio for BWV-401," said Joseph Hernandez, Chairman and Chief Executive Officer of BWV, in a press release on April 12, 2023.

"There remains a high unmet need for an efficacious Chlamydia vaccine to prevent the millions of infections worldwide each year."

According to the U.S. CDC, Chlamydia is the most frequently reported bacterial sexually transmitted infection in the U.S., with about 1.6 million new cases reported in 2020. 

As of April 30, 2023, no U.S. FDA-approved Chlamydia vaccines.

Apr 30, 2023 • 4:23 pm CDT
by Kon Zografos

The SCMP reported today that the Hong Kong Special Administrative Region of the People's Republic of China (HKSAR) recorded its fifth Mpox case. This 59-year-old patient had traveled to Guangdong province multiple times and was not linked to other Hong Kong cases as of April 30, 2023.

The initial Mpox patient was confirmed in September 2022 and presented with an infectious mononucleosis-like syndrome.

Since May 2022, over 100 countries have reported Mpox cases.

HKSAR's Health Department identified most of these cases among men. Mpox is caused by a sexually transmissible virus, and members of the public should seek medical attention if they experience symptoms such as fever, severe headache, muscle pain, swollen lymph node, mouth lesion, and rash.

Hong Kong's Mpox Vaccination Programme (JYNNEOS® (MVA-BN)) for high-risk groups began on October 5, 2022.

As of April 30, 2023, Mpox vaccines and treatments (TPOXX® (Tecovirimat)) were available in most countries.

However, recent research indicates breakthrough cases are being reported post-therapy.

Separately, the U.S. CDC recommends various routine and travel vaccination before visiting Hong Kong in 2023.

Apr 30, 2023 • 3:34 pm CDT
TSA airport screening April 30, 2023

According to new data from the U.S. Transportation Security Administration (TSA), getting through airport security can be measured in minutes.

During March 2023, about 89% of TSA PreCheck® passengers waited less than 5 minutes to be processed at 200 airports in the U.S.

And the TSA makes this special service a family affair.

Children 12 and under can join a parent/guardian with TSA PreCheck® in the dedicated lanes.

Speeding through security is essential as the number of air travelers has returned to pre-pandemic levels.

As of the week ending April 27, 2023, TSA screening activity has matched 2019.

Passenger screening at the airport is part of TSA’s layered approach to security to get you safely to your destination. Search at this webpage to learn when TSA PreCheck® lanes are available at your airport.

Note: You do not need to get TSA PreCheck® if you already have Global Entry, NEXUS, SENTRI, or hold an active TWIC® or Commercial Driver’s License with an HME and you meet the TSA PreCheck® eligibility requirements.

Apr 30, 2023 • 11:55 am CDT
Costa Rica malaria outbreak April 28, 2023

According to data recently announced from the Health Surveillance Directorate of the Costa Rican Ministry of Health, during epidemiological week #16, the Huetar Caribbean Region registered a marked decrease in malaria cases in the cantons of Limón and Pococí.

As of April 28, 2023, Limón reported 19 cases during week #15, while for week #16, 5 patients were registered, and for week #17, just 3 cases were reported, offering evidence of a significant decrease.

Furthermore, no malaria cases were identified in the canton of Talamanca, which corresponds to the South Caribbean, despite active inter-institutional searches in the border area with Panama and passive pursuits.

During the last weeks, the containment actions established by the Ministry of Health in conjunction with the Costa Rican Social Security Fund have been maintained, such as exhaustive tracking of all people in contact with confirmed cases.

Malaria is a disease caused by a parasite that spreads to humans through the bite of an infected mosquito.

Previously, the U.S. CDC issued an Alert - Level 2, Practice Enhanced Precautions confirming an outbreak of Plasmodium falciparum malaria in Limón and Alajuela Province.

Malaria can be prevented by taking a prescription antimalarial drug to kill the parasites, and in some countries, other than the U.S., malaria vaccines are available as of April 30, 2023.

Apr 28, 2023 • 4:02 pm CDT
U.S. CDC April 28, 2023

The U.S. Centers for Disease Control and Prevention (CDC) today announced two additional influenza-associated pediatric fatalities were reported last week.

A total of 145 pediatric flu fatalities have been reported during the 2022-2023 season as of April 28, 2023.

The previous peak in pediatric fatalities was 199 during the 2019-2022 flu season before the COVID-19 pandemic closed society.

And based on National Center for Health Statistics Mortality Surveillance data available on April 27, 2023, about 7.5% of the fatalities during the week ending April 22, 2023 (week #16) were due to pneumonia, influenza, and/or COVID-19.

Most influenza viruses tested are in the same genetic subclade and antigenically similar to the influenza viruses included in this season’s influenza vaccine.

These flu shots remain available at most community pharmacies in the U.S.

Apr 28, 2023 • 3:44 pm CDT
U.S. FDA letter April 28, 2023

The U.S. Food and Drug Administration (FDA) issued a letter today updating Pfizer Inc.'s COVID-18 vaccine authorization.

Addressed to Pfizer's Leslie Sands on April 28, 203, the new authorization for the Pfizer-BioNTech COVID-19 Vaccine, Bivalent for individuals six months through 4 years of age with certain types of immunocompromised, who have previously received three 0.2 mL doses (Pfizer-BioNTech COVID-19 Vaccine or Pfizer-BioNTech COVID-19 Vaccine, Bivalent):

  • a fourth dose administered at least one month following the most recent dose;
  • additional doses may be administered at the healthcare provider's discretion, considering the individual's clinical circumstances.

This issue was discussed during the U.S. CDC's Advisory Committee on Immunization Practices meeting on April 19, 2023.

Apr 28, 2023 • 10:27 am CDT
WHO Mpox map April 28, 2023

The World Health Organization (WHO) published the 21st situation report for the multi-country outbreak of mpox. Issued on April 27, 2023, the report offers an update from the WHO Eastern Mediterranean region.

Since April 13, 2023, 183 new Mpox cases (0.2% increase in total cases) and 14 new related fatalities have been reported to WHO.

From January 2022 through April 24, 2023, a cumulative total of 87,113 laboratory-confirmed cases of mpox, including 130 fatalities, have been reported from 111 countries/territories/areas.

For example, the Nation recently reported Pakistan had confirmed its fifth Mpox case related to international travelers.

According to sources, on April 27, 2023, three passengers arrived in Karachi on two flights from UAE on April 26 and were having symptoms of Mpox.

Previously, two Mpox cases were detected in Islamabad, originating from travelers from Saudi Arabia.

In response, the Director General of Health Services Sindh issued directives to all government hospitals to establish isolation areas for Mpox patients.

Mpox is a vaccine-preventable disease, according to the U.S. CDC. Throughout the Mpox outbreak, Bavarian Nordic's JYNNEOS® (MVA-BN) vaccine has been offered in various countries, including the U.S.

Apr 28, 2023 • 9:40 am CDT
by Neil Dodhia

In the United States, there remains a considerable burden of disease attributed to serotypes not included in currently approved pneumococcal conjugate vaccines.

To address this need, Pfizer Inc. today announced that the U.S. Food and Drug Administration (FDA) had approved PREVNAR 20® for the prevention of invasive pneumococcal disease (IPD) caused by the 20 Streptococcus pneumoniae serotypes contained in the vaccine in infants and children six weeks through 17 years of age.

And for preventing otitis media in infants six weeks through five years of age caused by the original seven serotypes contained in PREVNAR®.

"Today's FDA approval of our vaccine, PREVNAR 20, now offers parents the ability to help protect their children against 20 pneumococcal serotypes in circulation, which represent the majority of pneumococcal disease in U.S. infants and children," said Annaliesa Anderson, Ph.D., Senior Vice President and Chief Scientific Officer, Vaccine Research and Development, Pfizer, in a press release on April 27, 2023.

"This important PREVNAR 20 approval builds on more than 20 years of real-world impact with PREVNAR and PREVNAR 13, safety data, and effectiveness, highlighting Pfizer's leadership in developing groundbreaking pneumococcal conjugate vaccines to help protect infants and their families from life-threatening infections."

Pneumococcal vaccine news is posted by Precision Vaccinations.

Apr 27, 2023 • 7:37 pm CDT
USGS - Water Science School - April 2023

A National Academies committee recently assessed the value of community-level wastewater surveillance in controlling infectious diseases beyond Covid-19, wrote a Perspective published by the NEJM on April 20, 2023.

Nearly 80% of U.S. households are connected to municipal wastewater collection systems that contain biological waste, including discharged pathogens, such as poliovirus, in New York.

To better understand this innovative, ubiquitous method of detecting the prevalence of infectious diseases, listen to an interview with Profs. Michelle Mello and Guy Palmer focused on wastewater surveillance.

The 14:19 audio interview is accessible at this link.