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According to recent travel advisories issued by the United States government, visiting the Republic of Uganda is not encouraged in 2025.
On April 23, 2025, the U.S. Department of State reissued a Level 3: Reconsider Travel advisory for Uganda, a country home to approximately 32 million people, located in East Africa.
The State Department says visitors should exercise increased caution in Uganda due to security risks and ongoing civil unrest.
If you decide to travel to Uganda, enroll in the Smart Traveler Enrollment Program to receive alerts from the U.S. Embassy in Kampala. This free digital offering makes it easier to locate people in an emergency.
From a health perspective, Uganda is confronting multiple disease outbreaks in 2025.
Building on sustained U.S. technical support to Uganda since the first day of the 2025 Ebola outbreak, the United States government has now donated 100 vials of monoclonal antibodies (mAb) to the Uganda Ministry of Health. As a breakthrough in medical science, mAb has the potential to significantly improve survival rates in patients with Ebola.
U.S. Ambassador Popp stated in a press release on April 14, 2025, “Providing these groundbreaking treatments demonstrates the United States’ strong commitment to innovation, scientific excellence, shared prosperity, and global health security. As we respond to outbreaks like Ebola, we build stronger global health security partnerships that benefit us all.”
And will enhance the ongoing efforts to end the current Sudan Ebola Virus outbreak in Uganda, as no vaccines or therapeutics have been approved for the prevention or treatment of SVD in 2025.
Additionally, the CDC has included Uganda in its polio and mpox travel advisories and recommends pre-arrival vaccinations for several routine and travel-related diseases, such as yellow fever, mpox, and cholera.
Travel vaccines for these diseases are commercially available at clinics and pharmacies in the United States.
When the World Health Organization announced polio outbreaks remained a Public Health Emergency of International Concern for an additional three months, other health agencies reacted with more detailed disclosures focused on outbreaks.
For example, on April 22, 2025, the U.S. Centers for Disease Control and Prevention (CDC) reissued a Global Polio Alert—Level 2 advisory regarding polio outbreaks and poliovirus detections in 38 countries.
And the updated European CDC dashboard revealed that vaccine-derived poliovirus type 2 (cVDPV2) was detected in wastewater systems of 14 cities across five European countries in 2025.
In the Pacific Ocean area, a cVDPV2 environmental sample has been reported from Lae City, Morobe Province, Papua New Guinea. Located north of Australia, this country previously confirmed that poliovirus was circulating in 2018.
Both the CDC and ECDC recommend that adults who have previously completed the routine polio vaccine series receive a single, lifetime booster dose of polio vaccine before traveling to any destination listed.
In the United States, the IPV polio vaccine is available for purchase at most pharmacies.
The World Health Organization (WHO) recently published its multi-country outbreak of cholera, external situation report #25, which indicates various countries continue to be severely impacted by this vaccine-preventable disease.
This year, a cumulative total of 116,574 cholera cases and 1,514 deaths were reported from 25 countries across three WHO regions, with the African Region recording the highest numbers.
In the Caribbean, a total of 1,298 suspected cholera cases, including 19 deaths, were reported in Haiti, especially noted in Cité Soleil and Arcahaie.
In March 2025, 517 cholera-related deaths occurred, highlighting an 8% decrease from February 2025.
The WHO announced some positive news on April 22, 2025: the average stockpile of Oral Cholera Vaccine (OCV) had stabilized at 5.2 million doses, marking the fourth consecutive month with a stockpile above the five million doses needed for the emergency stockpile at all times.
However, the growing global demand continues to exceed supply, hindering efforts to control cholera outbreaks, respond rapidly to the disease’s spread, and implement preventive campaigns, according to the WHO.
In the United States, travel clinics and pharmacies currently have ample access to OCVs.
The Global Polio Eradication Initiative (GPEI) recently reported that one Circulating vaccine-derived poliovirus type 2 (cVDPV2) positive environmental sample was collected in March 2025 from Lae City, Morobe Province, the Independent State of Papua New Guinea (PNG).
As of April 22, 2025, GPEI reported that no associated cases of paralysis have been detected.
Nevertheless, PNG health authorities in the country are treating this event as high risk and have officially notified the World Health Organization (WHO) through the International Health Regulations, implementing measures to address the situation.
In April 2025, the WHO announced that the spread of the poliovirus remained a Public Health Emergency of International Concern. The WHO states that cVDPV2 poses a public health threat, affecting 27 countries across four regions.
PNG is classified as a developing nation, located in the southwestern Pacific Ocean north of Australia, with a land border with Indonesia. The Indonesian government reported a polio outbreak in Aceh province, linked to cVDPV2 in 2022.
Papua New Guinea previously confirmed that poliovirus was circulating in 2018.
To alert international travelers, the U.S. CDC reissued a Global Polio Alert—Level 2, Practice Enhanced Precautions Travel Health Notice on April 22, 2025, regarding polio outbreaks and poliovirus detections in 38 countries, including Indonesia, but not PNG.
The CDC recommends that travelers to these areas be fully vaccinated against this severe disease.
The Ministry of Health for the Federative Republic of Brazil recently confirmed a total of 1,019,033 dengue cases and 681 related fatalities this year.
As of April 12, 2025, São Paulo had reported the most dengue cases, at 590,850.
As of April 22, 2025, the U.S. Centers for Disease Control and Prevention (CDC) has identified more cases of dengue (1,481) than expected among U.S. travelers returning from countries with dengue outbreaks.
In 2025, 54 travel-associated and one locally acquired dengue cases were reported in Florida.
Of dengue's four types, DENV-3 is the most common serotype identified, accounting for 84%.
To alert travelers to Brazil and other areas, the CDC reissued a Global Travel Health Notice on April 15, 2025, regarding Dengue outbreaks in the Americas. Additionally, the CDC encourages healthcare providers to increase testing of patients with symptoms related to dengue.
Currently, dengue vaccines are unavailable in the U.S.
