Search API | Vax-Before-Travel

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The U.S. Centers for Disease Control and Prevention (CDC) recently announced that beginning early January 5, 2023, there are new requirements for air passengers two years of age and older traveling to the U.S. from China, Hong Kong, or Macau.

And these requirements apply to those traveling from Seoul, Toronto, and Vancouver who have been in China, Hong Kong, or Macau to the U.S. in the past ten days.

The CDC's Alert - Level 2, Practice Enhanced Precautions, issued on December 28, 2022, says to reconsider travel to China, Hong Kong, and Macau due to the rapid increase in COVID-19 cases and limited healthcare resources.

These changes are created to China ending its Zero-COVID policy in late December 2022.

In addition to COVID-19 vaccinations, the CDC suggests various travel vaccines before revisiting China.

Previously, the U.S. Department of State revised its Level 3: Reconsider Travel on December 22, 2022.

This travel advisory says mainland Peoples Republic of China visitors should prepare to be tested for COVID-19 and to quarantine at a government-designated location upon arrival.

U.S. citizens in China can visit a local embassy for assistance, such as the U.S. Embassy in Beijing, located ta No. 55 An Jia Lou Road, Chaoyang District, Beijing 100600, China.

Vaccine Treats:

COVID-19

Image:

Image Caption:

U.S. Dept. of State

Live Blog Update Author:

Don Hackett

Location Tags:

Macau

Vaccine:

CoronaVac COVID-19 Vaccine (Sinovac)

Polio Outbreaks

Poliovirus Outbreaks September 2025

The World Health Organization (WHO) confirmed during the 42nd meeting of the IHR Emergency Committee for Polio in June 2025 that the spread of the poliovirus remained a Public Health Emergency of International Concern (PHEIC) and updated its polio outbreak map. As of September 2025, the Global Polio Eradication Initiative (GPEI) confirmed that various countries had reported cases of wild poliovirus type 1 (WPV1), circulating vaccine-derived poliovirus type 2 (cVDPV2), vaccine-derived poliovirus type 2 (VDPV2), and circulating vaccine-derived poliovirus type 1 (cVDPV1).

The U.S. Centers for Disease Control and Prevention (CDC) reissued a Global Polio Alert—Level 2, Practice Enhanced Precautions Travel Health Notice on August 4, 2025, regarding polio outbreaks and poliovirus detections in 41 countries. The CDC published an MMWR on March 6, 2025, confirming that the Nigeria virus lineage had been detected in wastewater samples in 16 cities across five European countries. On October 17, 2024, the CDC announced (MMWR Vol. 73 , No. 41) that from January 2023 to June 2024, 74 cVDPV outbreaks were detected in 39 countries, with 672 confirmed cases of acute flaccid paralysis (AFP) identified in 27 countries. Less than 1% of wild poliovirus infections result in Acute Flaccid Paralysis (AFP). In 2024, the GPEI reported 243 cases of AFP worldwide.

Polio Cases in the Americas

The WHO / Pan American Health Organization (PAHO) issued an Epidemiological Update (Year 39, 51-52) - Poliomyelitis in the Americas Region and reported AFP Surveillance in 2024. The PAHO/WHO reminds Member States that the risk of the emergence of a cVDPV1 or circulating vaccine-derived poliovirus type 3 (cVDPV3) has increased due to low vaccination coverage. In addition, the PAHO/WHO reports a continuing risk of importing a WPV1 or VDPV, mainly cVDPV2. cVDPV2 cases peaked in 2020, with over 1,000 cases of paralysis in 24 countries. As of January 2025, the PAHO reported 1,856 AFP cases in 2024.

Polio in the United States

The United States was added to a list identified with polio in 2022. The CDC reported (Volume 30, Number 11—November 2024) that wastewater surveillance for poliovirus identified ongoing transmission of poliovirus in Rockland County and adjacent New York counties in 2022. In June 2022, a case of paralytic polio caused by VDPV2 was identified in an unvaccinated adult in Rockland County, New York. In addition, poliovirus type 2, genetically linked to the VDPV2 isolated from the patient, was detected in wastewater samples from Rockland and several surrounding counties, indicating community transmission. This case was the first known case of paralytic polio in the U.S. since 2013 and the first documented instance of community transmission of poliovirus in the U.S. since 2005. The New York State Department of Health (NYSDOH) confirmed the presence of poliovirus in wastewater in March 2023 and October 2024. The CDC states that the detection of poliovirus in wastewater cannot be used to determine the total number of infected individuals in a community or the proportion of the infected population. The minimum number of infected individuals that can be reliably detected through wastewater testing is not known.

The International Health Regulations classify the U.S. as a country or state infected with cVDPV2, with or without evidence of local transmission. Therefore, the U.S. is subject to Temporary Recommendations issued by the International Health Regulations Emergency Committee on Polio Eradication.

Afghanistan Polio Outbreak

Afghanistan is affected by the ongoing endemic transmission of wild poliovirus. In 2024, 25 WPV1 cases were reported. In 2023, 18 WPV1-positive environmental samples were reported. According to the Ministry of Health, Afghanistan detected its initial human polio case in May 2023. As of June 2, 2023, local media reported four confirmed cases of polio in the province of Nangarhar. Two polio patients were confirmed in 2022, four in 2021, and 56 in 2020.

Africa Polio Outbreaks

Kenya's Ministry of Health announced on October 1, 2024, that five polio cases have been confirmed, and one positive environmental surveillance sample has been taken in Kamukunji Sub-County, Nairobi. In June 2024, Somalia launched a significant polio vaccination campaign for children. On May 24, 2024, Angola reported AFP and environmental detections. On May 14, 2024, the closure of the WPV1 outbreaks in Malawi and Mozambique was announced. Over 100 million vaccine doses have been administered in the areas most at risk. Zimbabwe is inoculating more than 4 million children against polio in February 2024, following the detection of three cases caused by a rare mutation of the weakened virus in oral vaccines.

Australia Poliovirus Detections

On December 2, 2024, Australia's poliovirus surveillance program detected vaccine-derived poliovirus in pre-treated sewage from the Western Treatment Plant in Melbourne. This detection is likely linked to an individual who received a live polio vaccine and shed the virus in Victoria. Australia remains polio-free, as there has not been a detection of wild-type poliovirus.

South-East Asia Polio Outbreaks

Singapore reported one polio case in February 2025. Indonesia reported four instances of cVDPV2 from October 2022 to February 2023. In late December 2023, the Indonesian Ministry of Health notified WHO of two new confirmed cases of cVDPV2. Despite Indonesia having a strong capacity to respond to poliovirus outbreaks and West Java having a moderate to strong outbreak response capacity to interrupt transmission, the population remains highly susceptible to poliovirus type 2 after switching from trivalent to bivalent OPV. The ongoing polio outbreak in Indonesia poses a high risk at the national level, a moderate regional threat, and a low global risk as of 2024. The GPEI published a report of the Indonesia Polio Outbreak Response Assessment – July 2023. BMC Public Health published in March 2021 - Scaling up public health interventions: a case study of the polio immunization program in Indonesia.

Europe Polio Outbreaks

This Eureopen CDC dashboard provides an overview of the global poliovirus situation in April 2025. The European Centre for Disease Prevention and Control (ECDC) published an interactive map in 2025 displaying countries currently confirming polio or poliovirus cases. From September through December 2024, vaccine-derived poliovirus type 2 (VDPV2) was detected in wastewater systems of 14 cities in five European countries. The isolated VDPV2 viruses are linked to a lineage (NIE-ZAS-1) first detected in Nigeria in July 2020. Poliovirus has been detected in Germany, Finland, Poland, and Spain. Poland's health ministry confirmed that a sample of municipal sewage collected in Win 2024 Warsaw in 2024 revealed the presence of poliovirus type 2. The last poliovirus cases in Poland were recorded in 1982 and 1984. Finland's Institute for Health and Welfare identified VDPV2 in wastewater samples from Tampere in 2024. The WHO declared the European Region polio-free in 2002.

India Polio Outbreaks

The World Health Organization declared India polio-free in 2014. National Immunization Days are held twice a year across India, and the government aims to administer two drops of OPV to every child under five, as reported by The Times of India in 2023. Polio vaccination campaigns for children are expected to continue in 2024.

Israel Polio Outbreaks

The Global Polio Eradication Initiative reported on August 4, 2025, that Israel confirmed six environmental samples of circulating vaccine-derived poliovirus type 1 (cVDPV1), five from Jerusalem and one from Center. On April 24, 2025, the Ministry of Health's Central Virus Laboratory in Israel detected poliovirus in an environmental sample in the Jerusalem area. In March 2025, Israel discontinued offering the live attenuated polio vaccine (oral). It now provides the IPV. As of March 2023, four VDPV3-positive polio cases in children were confirmed. On February 27, 2023, the Israeli Ministry of Health issued an official alert describing a local case of Acute Flaccid Paralysis (AFP). As of April 15, 2022, a total of seven VDPV3-positive cases were confirmed. A cluster of VDPV3 was previously detected in environmental samples from Jerusalem and Bethlehem city, collected between September 2021 and January 2022.

Gaza Strip Polio Outbreak

In February 2025, the WHO confirmed a polio case that had occurred in August 2024. New environmental samples from Deir al Balah and Khan Younis, collected in December 2024 and January 2025, confirm the transmission of poliovirus, genetically linked to the poliovirus detected in the Gaza Strip in July 2024.

Pakistan Polio Outbreaks

In 2025, 3 WPV1 cases were reported. In 2024, 73 WPV1 cases were confirmed, and numerous WPV1-positive environmental samples were reported this year. Of these, 27 were from Balochistan, 22 from Khyber Pakhtunkhwa, 22 from Sindh, and one from Punjab and Islamabad. In 2022, 20 WPV1 cases and 20 paralyzed children were reported in the southern KP province.

South America Poliovirus Detections

The Pan American Health Organization (PAHO) published an alert on October 14, 2024, confirming the detection of circulating vaccine-derived poliovirus type 3 (cVDPV3) in wastewater samples collected in Cayenne, French Guiana. Additional testing identified positive samples collected in Remire-Montjoly and Saint-Georges-de-l'Oyapock. In 2024, the PAHO identified Argentina, Haiti, and Peru as at very high risk for the reintroduction of polio. In 2024, the PAHO reported that 176 virus isolation test results were pending in the Americas.

Spain Poliovirus

In Spain, circulating vaccine-derived poliovirus type 2 (cVDPV2) was isolated from a single positive sample collected in Barcelona for the first time in September 2024.

United Kingdom Poliovirus

In December 2024, one cVDPV2-positive environmental sample was collected in London. Five cVDPV2-positive environmental samples were collected in November 2024 from Yorkshire and the Humber, the South East, and London in the U.K. The UKHSA National Polio Guidelines outline public health actions to be taken when a cVDPV2 is detected in environmental samples. In May 2022, six positive samples were reported following the isolation of VDPV2 from ecological samples in London. U.K. public health authorities continue to intensify surveillance efforts, including for potential cases of paralysis, offering an additional dose of inactivated polio vaccine to all children across London.

Polio Vaccines

As of April 2025, various polio vaccines are available worldwide. Due to the high vaccination rate (93%), the CDC reports very few cases of polio. According to the CDC, the IPV has been the only vaccine in the U.S. since 2000. The New York City Health Department and the CDC recommend that adults who received polio vaccines as children receive a one-time lifetime IPV booster dose if traveling to an area with poliovirus transmission.

9 min read

Reviewer:

Robert Carlson, MD

Last Reviewed:

Tuesday, September 2, 2025 - 09:35

Description:

Poliovirus detections continue in 2025. Polio is a vaccine preventable disease according to the U.S. CDC, WHO, and European Medicines Agency.

Condition:

Polio

Malaria Outbreaks

Malaria Outbreaks September 2025

According to the World Health Organization (WHO) Malaria Report 2024, eleven out of 83 malaria-endemic countries had the highest rates of infections and deaths in 2023. According to the WHO, despite an annual expenditure of $4 billion, malaria deaths and cases have not shown substantial change over the last decade. The WHO African Region bears the heaviest burden of malaria disease. The WHO's malaria report estimated 263 million malaria cases and 597,000 related fatalities worldwide in 2023. This data represents about 11 million more cases than in 2022.

On World Malaria Day 2025, the WHO calls for revitalized efforts at all levels, from global policy to community action, to accelerate progress towards malaria elimination. Malaria infections are often misdiagnosed; however, commercial lab testing services can detect malaria infections. As of June 2025, the WHO Guidelines for Malaria include updated recommendations for malaria vaccines, primaquine, and tafenoquine. The WHO recommends the use of malaria vaccines for the prevention of P. falciparum malaria in children living in malaria-endemic areas, such as Africa.

The Institute for Health Metrics and Evaluation publishes estimates of malaria-related mortality. The Atlasvisualdelamalaria.org is a project of the iO Foundation, which published malaria information in 2025.

Malaria Cases in the United States 2025

The U.S. Centers for Disease Control and Prevention (CDC) says millions of residents travel to countries where Malaria is present. As of week 14, ending April 5, 2025, the CDC confirmed 545 malaria cases in the United States, with New York City and Maryland leading the way. During 2024, the CDC confirmed 436 cases.

The CDC published MMWR Volume 30, Number 7—July 2024, Research Letter, which reported that about ten Plasmodium vivax malaria cases were confirmed at an institution in Los Angeles, California, in 2023. The CDC published a Report on September 8, 2023, confirming eight cases of autochthonous Malaria were reported by state health departments in Florida (Sarasota, seven) and Texas (one) in Cameron County from May 18 to July 17, 2023. On October 24, 2024, the CDC reported (73(42);946–949) nine local malaria cases from May to August 2023, followed by a 10th case of locally acquired Malaria diagnosed in Arkansas. On August 6, 2023, Maryland reported one local case of Malaria.

In March 2025, Florida reported eight cases of travel-related Malaria. As of December 2023, Florida Health reported over 71 cases of Malaria related to international travel. In 2003, 8 cases of locally acquired P. vivax malaria were identified in Palm Beach County, FL. The Texas Department of State Health Services (DSHS), Amira Bashadi, MPH, reported on February 16, 2024, that from 2013 to 2022, 1,239 cases of Malaria were reported in Texas. In 2022, there were 166 malaria cases in Texas. Of these, the majority (98%) were acquired from international travelers from Africa, Asia, and South America.

In 2019, 2,048 malaria cases, most associated with travel to 85 countries where Malaria remains endemic, were reported to the CDC.

Malaria Outbreaks in Africa

The WHO reports that four African countries are responsible for over 50% of all malaria deaths worldwide: Nigeria (31.3%), the Democratic Republic of the Congo (12.6%), the United Republic of Tanzania (4.1%), and Niger (3.9%).

Malaria Outbreaks in the Region of the Americas

In 2024, the Pan American Health Organization (PAHO) estimated that 41 million people live in 21 areas where the risk of infection by mosquito-carrying Malaria is considered moderate to high. Eighteen countries, including one territory in the Americas, are currently at risk of Malaria. Countries in the Region of the Americas reported 505,000 malaria cases in 2023, a 5% increase from 2022, when the PAHO reported 481,788 cases and approximately 92 deaths, and in 2023, around 520,000 cases and 120 deaths were reported.

In the Region Americas, during the construction of the Panama Canal, approximately 30,000 people lost their lives to infectious diseases common in the tropical environment, Malaria. Panama reported a total of 15,109 malaria cases in 2024, up from 11,659 cases in 2023.

The Argentine Republic Ministry of Health confirmed local malaria transmission in Santa Elena Town and Cristo Rey Village in the Cayo District in April 2025. In December 2023, the Costa Rica Health Surveillance Directorate of the Ministry of Health announced an increased risk of Malaria in Costa Rica, especially in coastal zones. Costa Rica reported over 544 malaria cases in 2022 and 406 locally acquired malaria cases in 2021. The CDC issued various outbreak alerts for malaria-endemic countries, including Costa Rica.

In 2023, the WHO certified Paraguay, Argentina, and El Salvador as malaria-free in 2018, 2019, and 2021, respectively. Additionally, the WHO certified Belize malaria-free on June 21, 2023.

The Trinidad and Tobago Ministry of Health reported eight cases of Malaria in 2025.

A study published by the Royal Society on February 15, 2023, indicates malaria-carrying mosquitoes are gaining an average of 6.5 meters (21 feet) of elevation per year, and the southern limits of their ranges are moving by 4.7 kilometers (nearly 3 miles) from the equator per year.

Malaria Outbreaks in Australia

Australia was certified by the World Health Organization (WHO) as malaria-free in 1981. However, the re-establishment of malaria and local transmission in Australia has occurred.

Malaria Outbreaks in China

China was declared malaria-free by the World Health Organization in 2021, and no indigenous cases of Malaria have been reported since 2016. In China, the malaria burden was reduced from 30 million cases per year in the 1940s to zero indigenous cases in 2017.

Malaria Outbreaks in Europe

As of April 2024, malaria-carrying mosquitoes have been detected in Greece (since 2021) and along Italy's southeastern coast. The European CDC published the Surveillance Atlas, which reported travel-associated malaria cases in Europe from 2018 to 2022.

Malaria Outbreaks in India

In 2022, 50 people died of Malaria across India. However, this was a drastic decrease from 2014, when 562 deaths were attributed to Malaria. The National Framework for Malaria Elimination in India (2016-2030) was launched in 2016, followed by the National Strategic Plan (2017-2022). According to the WMR 2019, India represents 3% of the global malaria burden.

Malaria Mexico

On November 7, 2023, The Lancet published an article titled "The U.S.–Mexico border and falciparum malaria." The U.S. CDC recommends that travelers to certain areas of Mexico take prescription medicine to prevent Malaria. Depending on your medication, you must start taking this medicine multiple days before, during, and after your trip.

Malaria in South Korea

In April 2025, South Korean military personnel were treated for malaria infections. In 2024, the Korea Disease Control and Prevention Agency issued a nationwide malaria alert. According to the Korea Disease Control and Prevention Agency, over 719 malaria cases were confirmed from January to mid-October 2023. This is the first time the annual number of malaria cases has topped 700 since 2011.

Malaria United Kingdom

Provisional UKHSA data indicate that imported malaria cases decreased to 1,812 in 2024, down from 2,106 in 2023. Most malaria cases were reported during peak summer travel months between July and October, and in the London area.

Malaria

Malaria is a curable disease caused by four species of protozoan parasites of the genus Plasmodium: P. falciparum, P. vivax, P. malariae, and P. ovale, and is transmitted to people by Anopheles mosquitoes.

Zoonotic Avian Malaria Outbreaks

Zoonotic forms of Malaria have been documented as causes of human infections and some deaths, especially P. knowlesi, a parasite of Old World (Eastern Hemisphere) monkeys in Southeast Asia. Avian Malaria is a disease caused by a species of protozoan parasites (Plasmodium) that infect birds. It has caused mortalities in captive penguins worldwide. A study published in 2021 concluded that penguins' susceptibility, translocation across institutions, and the wide distribution of avian Malaria make this disease a constant threat.

Malaria Vaccines 2025

Malaria vaccine information is posted on Vax-Before-Travel as of 2025.

7 min read

Reviewer:

Robert Carlson, MD

Last Reviewed:

Monday, September 1, 2025 - 14:25

Description:

Malaria is vaccine preventable disease caused by parasites transmitted to people by infected mosquitoes.

Condition:

Malaria

BNT165 Malaria Vaccine

BNT165 Malaria Vaccine 2023

BioNTech SE is developing the first Messenger RNA (mRNA)-based vaccine candidate for Malaria prevention. BNT165b1 is a vaccine that expresses certain parts of the circumsporozoite protein (CSP). This vaccine candidate is based on a novel multi-antigen vaccine approach. BioNTech is evaluating a set of mRNA-encoded antigens of the malaria-causing parasite Plasmodium falciparum (P. falciparum) to help select the multi-antigen vaccine candidate to proceed to planned later-stage trials.

In December 2022, BioNTech initiated a Phase 1 clinical trial of BNT165b1 to evaluate the safety, tolerability, and exploratory immunogenicity of the vaccine candidate. A data update is expected in 2H 2023. The Estimated Study Completion Date is September 2024.

Biopharmaceutical New Technologies (BioNTech) is a next-generation immunotherapy company located in Mainz, Germany, pioneering novel therapies for cancer and other serious diseases.

BNT165 Indication

Malaria is a life-threatening disease caused by parasites transmitted to people through the bites of infected female Anopheles mosquitoes. The World Health Organization (WHO) estimated on December 8, 2022, that there were over 247 million cases of Malaria and 619,000 associated deaths in 2021. The WHO African Region was home to 95% of malaria cases and 96% of malaria deaths. Children under 5 accounted for about 80% of all malaria deaths in the Region.

BNT165 Vaccine News

December 23, 2022 - BioNTech announced the initiation of a first-in-human Phase 1 study with BNT165b1, the first candidate from the Company’s BNT165 program, to develop a multi-antigen malaria vaccine candidate. “The trial initiation is an important milestone in our efforts to help address diseases with high unmet medical need. Our objective is to develop a vaccine that can help to prevent Malaria and reduce mortality. Over the next few months, we aim to evaluate different antigens with scientific rigor to identify the optimal candidate,” said Prof. Özlem Türeci, M.D., Chief Medical Officer and Co-Founder of BioNTech.

July 26, 2021 - BioNTech announced the launch of its Malaria project, which aims to develop a well-tolerated and highly effective Malaria vaccine and implement sustainable vaccine supply solutions on the African continent.

BNT165 Clinical Trial

Clinical trial NCT05581641 has not begun recruiting as of December 23, 2022. BioNTech’s placebo-controlled, observer-blinded Phase 1 dose escalation trial is expected to enroll approximately 60 healthy volunteers with no history of previous or current malaria infection throughout several sites in the United States. BNT165b1 will be evaluated at three dose levels.

0 min read

Manufacturer:

BioNTech

Reviewer:

Robert Carlson, MD

Vaccine:

BNT165 Malaria Vaccine

Availability:

N/A

Generic:

BNT165

Drug Class:

mRNA vaccine

Clinical Trial Phase I:

Investigational RNA-based Vaccine Against Malaria

Condition:

Malaria

Last Reviewed:

Monday, March 27, 2023 - 14:55

Status:

Candidate

Manufacturer Country ID:

FDA First In Class:

Yes

BNT163 Herpes Vaccine

BNT163 Herpes Vaccine Clinical Trials, Dosage, Indication, Side Effects

BioNTech SE's BNT163 herpes simplex virus (HSV) vaccine candidate is under development to prevent genital lesions caused by Herpes Simplex Virus-2 (HSV-2) and potentially Herpes Simplex Virus-1 (HSV-1). Based on the Company's Messenger RNA (mRNA) platform, BNT163 encodes three HSV-2 glycoproteins to help prevent HSV-2 cellular entry and spread, as well as to counteract the immunosuppressive properties of HSV-2. BNT163 is an anti-viral ribonucleic acid (RNA) vaccine candidate from BioNTech's infectious disease mRNA vaccine collaboration with the Perelman School of Medicine at the University of Pennsylvania (Penn) in Philadelphia to enter the clinic. The program is Part of BioNTech's strategy to address diseases with a high unmet medical need.

Announced on December 21, 2022, BioNTech's placebo-controlled, observer-blinded, dose-escalation Phase 1 clinical trial is expected to enroll around 308 healthy volunteers aged 18 to 55 without current or history of symptomatic genital herpes infections in the U.S. The first subject was dosed on December 21, 2022. The study comprises a first-dose escalation part, focusing on safety evaluations and assessing the optimal dose-response across various dose levels. The trial's second Part is designed to expand the safety characterization of the selected BNT163 dosing for a more comprehensive assessment of the impact of pre-existing immunity to HSV-1 and -2 on safety and BNT163-induced immune responses. The ClinicalTrials.gov Identifier is NCT05432583, with an estimated study completion date of October 2026.

Currently, available HSV therapies only reduce the severity and frequency of symptoms, says the U.S. Centers for Disease Control and Prevention (CDC). As of 2025, the U.S. Food and Drug Administration (FDA) and other agencies have not authorized any herpes vaccine.

Based in Mainz, Germany, Biopharmaceutical New Technologies (BioNTech SE) (Nasdaq: BNTX) is a next-generation immunotherapy company pioneering novel therapies for cancer and other serious diseases.

BNT163 Indication

HSV-1 and HSV-2 viruses cause two highly prevalent viral infections, according to the World Health Organization (WHO). Both viruses are highly contagious and can also be transmitted during childbirth. As neurotropic and neuroinvasive viruses, HSV-1 and -2 persist in the body by hiding from the immune system in the cell bodies of neurons, where they reside lifelong and thus cannot be eradicated with current treatments. Once acquired, HSV persists lifelong in the body with recurring symptomatic outbreaks. HSV-1 is mainly transmitted by oral contact and causes lesions around the mouth, but in some cases, it also leads to genital infections and respective lesions.

HSV-2 is a sexually transmitted disease that causes genital herpes. Therefore, infections with HSV-2 further increase the risk of acquiring and transmitting HIV infections. According to the WHO, approximately 500 million people globally are estimated to be affected by genital infections caused by HSV-2, with painful genital lesions, an increased risk for meningitis, and high levels of emotional distress. Moreover, HSV-2 infection increases the risk of acquiring HIV infection by approximately threefold. In addition, co-infections with both HIV and HSV-2 increase the likelihood of transmitting HIV to others, says the WHO.

BioNTech - University of Pennsylvania

In 2018, Penn and BioNTech entered into a research collaboration and license agreement to develop novel mRNA vaccine candidates for the prevention and treatment of various infectious diseases. As a result, the Perelman School of Medicine at the University of Pennsylvania has licensed some intellectual property related to the BNT163 vaccine candidate to BioNTech. Additionally, the University receives sponsored research funding from BioNTech, associated with the preclinical development of the BNT163 vaccine candidate. As inventors of specific intellectual property related to the BNT163 vaccine candidate, some of the scientists involved in the preclinical development of the vaccine and Penn may receive additional financial benefits under the BioNTech license in the future. The Penn (BNT163-01) research study is being conducted to determine the optimal dose of the investigational vaccine, BNT163, and to assess its safety and tolerability.

BNT163 Herpes Vaccine News

February 23, 2023 - Herpes Vaccines Focus on mRNA.

December 21, 2022 - "This program is part of our strategy to help address diseases with a high unmet medical need and of global health relevance by combining our new technologies, such as mRNA, and our expertise in immune engineering," said Prof. Özlem Türeci, M.D., Chief Medical Officer and Co-Founder of BioNTech, in a press release. "BNT163 is based on three non-infectious mRNA-encoded HSV-2 glycoproteins. We aim to induce a broad immune response against multiple antivirus antigens and mobilize various immune effectors to support virus neutralization and clearance."

November 5, 2018 - BioNTech AG, a rapidly growing biotechnology company focused on the development of immunotherapies for the precise and individualized treatment of cancer and prevention of infectious diseases, and the University of Pennsylvania (Penn), Philadelphia, USA, today announced that they have entered into a strategic research collaboration. The exclusive, multi-year partnership aims to develop novel nucleoside-modified mRNA vaccine candidates for the prevention and treatment of various infectious diseases.

BNT163 Herpes Vaccine Clinical Trials

Phase 1 study: ClinicalTrials.gov Identifier: NCT05432583 - This exploratory trial will have two parts. While Part A will focus on safety evaluations, vaccine-induced immune responses, specifically neutralizing antibodies, will also be analyzed to assess whether there is a dose-response relationship. The trial will expand the safety characterization for a BNT163 dose selected based on Part A data and enable a more comprehensive assessment of the impact of pre-existing immunity to HSV-1 and -2 on the safety and BNT163-induced immune responses after one selected (higher) dose of BNT163 than could be done during the dose escalation performed in Part A.

0 min read

Manufacturer:

BioNTech SE

Reviewer:

Robert Carlson, MD

Vaccine:

BNT163 Herpes Vaccine

Availability:

N/A

Generic:

BNT163

Drug Class:

mRNA vaccine

Clinical Trial Phase I:

Vaccination With an Investigational Vaccine Designed to Prevent Genital Herpes Lesions

Condition:

Herpes

Last Reviewed:

Friday, December 12, 2025 - 09:55

Status:

Candidate

Manufacturer Country ID:

Location tags:

United States of America

Germany

Dukoral Cholera Vaccine

DUKORAL® Cholera Vaccine Clinical Trials, Dosage, Indication, Side Effects

Valneva SE's DUKORAL® is an oral, inactivated vaccine for preventing diarrhea caused by Vibrio cholerae and/or heat-labile toxin-producing enterotoxigenic Escherichia coli (ETEC). Since the 1980s, either killed or live oral cholera vaccines (OCVs) have been developed, and efficacy and effectiveness studies have been conducted. DUKORAL contains four different inactivated strains (types) of V. cholerae serotype O1 and part of a toxin from one of these strains as active ingredients, according to the European Medicines Agency (EMA). Dukoral is a vaccine administered orally to protect individuals against cholera. DUKORAL suspension and effervescent granules for oral suspension. DUKORAL's ATC code: J07AE01, J07AE02, J07AE51.

The World Health Organization (WHO) has prequalified the DUKORAL vaccine. It is authorized in Europe, Australia, Canada, Ireland, Mayotte, New Zealand, Switzerland, Thailand, and the United Kingdom to protect people against cholera and Enterotoxigenic Escherichia coli (ETEC). The EMA (EMEA/H/C/000476) states that Dukoral is used in individuals aged 2 years who will be visiting areas with a high risk of cholera. The WHO announced on February 12, 2024, that global demand for OCVs (74 million) has exceeded supply (38 million). Valneva announced on November 7, 2024, that DUKORAL sales in the third quarter of 2024 increased by 85% year-over-year, as marketing investments resumed following a successful regulatory inspection of the Company's new manufacturing site in Sweden.

France-based Valneva SE's strategy is rooted in its vision of contributing to a world where no one dies or suffers from a vaccine-preventable disease. Dukoral initially produced the SBL vaccine.

DUKORAL Cholera Vaccine Indication

The U.S. CDC recommends vaccination for people traveling to or living in areas of active cholera transmission. In addition, active immunization against disease caused by Vibrio cholerae serogroup O1 is recommended for adults and children (2 years and older) who will be visiting endemic/epidemic areas. But cholera vaccines are not 100% effective. Check the CDC's Travel Health Notices to identify areas with active cholera transmission.

DUKORAL Cholera Vaccine Dosage

DUKORAL is administered orally with a buffer solution that requires 150 ml of clean water for adults. The standard primary course for adults and children over six years old consists of two doses; children under six years old should receive three doses. Doses are to be administered at intervals of at least one week but less than six weeks apart. The primary immunization course should be restarted if more than six weeks have elapsed since the last dose. Immunization should be completed at least one week before potential exposure to Vibrio cholerae O1.

Each dose of DUKORAL vaccine suspension (3ml) contains a total of 1.25 x 1011 bacteria of the following strains: Vibrio cholerae O1 Inaba, classical biotype (heat inactivated) 31.25 x 109 bacteria, Vibrio cholerae O1 Inaba, El Tor biotype (formalin inactivated) 31.25x 109 bacteria, Vibrio cholerae O1 Ogawa, classical biotype (heat inactivated) 31.25x 109 bacteria, Vibrio cholerae O1 Ogawa, classical biotype (formalin inactivated) 31.25x 109 bacteria—recombinant cholera toxin B subunit (rCTB) 1mg.

DUKORAL Vaccine Production

Valneva's global manufacturing network comprises three in-house operations, covering both internal and external production of clinical and commercial products. Valneva's U.S. FDA-approved manufacturing site in Livingston, located just outside Edinburgh, is currently dedicated to producing drug substances for our viral vaccines. Valneva's manufacturing site in Solna is just outside of Stockholm. The site has a long history of vaccine manufacturing and is affiliated with Sweden's state-owned vaccine institute. Valneva's new manufacturing site in Sweden underwent regulatory evaluation and approval in 2024. Along with Valneva's development center in Vienna (Austria), the Company operates GMP laboratories and facilities for the testing and quality control of Valneva's commercial and clinical-stage vaccines.

DUKORAL Cholera Vaccine Warnings and Precautions

DUKORAL® confers protection specific to Vibrio cholerae serogroup O1. Immunization does not protect against V. cholerae serogroup O139 or other species of Vibrio. Administration of DUKORAL® should be postponed for subjects suffering from acute gastrointestinal or febrile illness. DUKORAL is not recommended for use in children under two years of age. Formaldehyde is used during manufacturing, and trace amounts may be present in the final product. Caution should be taken in subjects with known hypersensitivity to formaldehyde. DUKORAL contains approximately 1.1 g of sodium per dose, which patients should consider when following a controlled sodium diet. The vaccine does not provide complete protection against the disease.

Cholera Outbreaks

Various countries have reported cholera outbreaks in 2025.

DUKORAL Vaccine News

August 12, 2025 - In the first half of 2025, DUKORAL® sales were €17.4 million compared to €14.9 million in the first half of 2024. The supply of doses notably contributed to this 16.4% growth, supporting efforts to combat an outbreak on the French island of Mayotte, for a total of €1.1 million in the first quarter of 2025.

May 7, 2025 - Valneva SE reported that in the first quarter of 2025, DUKORAL sales increased 9.4% to €12.3 million, primarily driven by the supply of doses to the French Department of Mayotte.

December 18, 2024—The WHO reported that Oral Cholera vaccine production reached its highest level in November since 2013. This increase allowed the average stock to rise to 3.5 million doses in November, compared to 600,000 in October 2024.

March 20, 2024 - The Company confirmed that DUKORAL® vaccine sales benefited from the significant recovery in the private travel markets.

September 30, 2022 - Cholera Vaccine: Recommendations of the U.S. CDC Advisory Committee on Immunization Practices.

DUKORAL Clinical Studies

In September 2023, a Research Article focused on cholera vaccine clinical trials: A cross-sectional analysis of clinical trials registries.

Challenge studies in human volunteers provided the first demonstration of efficacy. The challenge study at the University of Maryland enrolled healthy participants aged 19 to 35. Participants receiving either WC-BS (with 5 mg of CTB) or WC were given three doses at 2-week intervals. In addition, Cimetidine was administered three hours before receiving the vaccine, along with the sodium bicarbonate solution mixed with the vaccine. Vaccinated participants and unvaccinated controls were challenged with 2 × 106 El Tor Inaba V. cholerae (strain N16961) four weeks after completion of the third dose of WC (n = 9) and five weeks after completion of WC-BS (n = 11). The vaccine efficacy of WC was found to be 56%, and for WC-BS, 64% (Table 2). Vaccinated participants in both groups who developed cholera had less severe illness than controls and complete protection from severe diarrhea.

The EMA states that the Company presented data from the published literature and the results of three central studies involving nearly 113,000 people to support the use of Dukoral. In all three studies, Dukoral, given in either two or three doses, was compared with a placebo (a dummy vaccine). The studies took place in areas where cholera was found. The primary measure of effectiveness was the 'protective effectiveness' of the vaccine, calculated by comparing the number of people in the studies who developed cholera after receiving Dukoral and a placebo.

The first study involved over 89,000 people in Bangladesh and compared Dukoral with the same vaccine without the toxin and with a placebo. In this study, Dukoral was formulated using the cholera toxin extracted from cholera bacteria, rather than the newer recombinant toxin. The protective effectiveness of Dukoral was 85% over a six-month period. Protection lasted for six months in children and two years in adults. In adults, two doses of the vaccine were as effective as 3.

The other two studies compared Dukoral (containing recombinant cholera toxin) with a placebo in over 22,000 people in Peru. In the first of two doses, Dukoral's protective effectiveness was 85% for the first five months after vaccination. The people in the second study also received a booster dose 10 to 12 months later. The protective effectiveness of Dukoral after the booster dose was 61% during the second year of follow-up.

0 min read

Manufacturer:

Valneva SE

Reviewer:

Robert Carlson, MD

Vaccine:

Dukoral Cholera Vaccine

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Australia, Canada, New Zealand, Europe, France, New Zealand, United Kingdom, and Thailand

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Cholera Vaccine

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Vaccine

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Clinical Trial Phase II:

Safety and Immunogenicity of Locally Manufactured New (HL-OCV) Oral Cholera Vaccine

Clinical Trial Phase III:

Oral Cholera Vaccine Efficacy and Effectiveness

Condition:

Cholera

Availability Link:

Europe

Last Reviewed:

Monday, September 15, 2025 - 07:35

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DUKORAL®

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07AE01

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J07AE01

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Approved

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United States of America

Cholera Outbreaks

Cholera Outbreaks September 2025

The World Health Organization (WHO) has recorded seven cholera pandemics over the past two centuries. The current (7th) cholera epidemic is considered to have started in 1961. As of September 2025, over 409,222 cholera/Acute Watery Diarrhoea cases and 4,738 deaths were reported globally, from 31 countries, with six of the 31 countries reporting case fatality rates above 1%. The WHO's Global Cholera and Acute Watery Diarrhoea Dashboard was updated in 2025. In 2024, 804,721 cholera cases and 5,805 related fatalities were reported from 33 countries. Data show that 472,697 cholera cases were reported to the WHO in 2022, up from 223,370 in 2021.

The U.S. Centers for Disease Control and Prevention (CDC) has identified an unprecedented global increase in cholera outbreaks over the last four years: 2022, 2023, 2024, and 2025. In addition, the Pan American Health Organization (PAHO) and the European CDC, and the WHO have reported active cholera transmissions in Angola, Benin, Cameroon, the Democratic Republic of the Congo, Eswatini, Ethiopia, India, Haiti, Kenya, Malawi, Mozambique, Myanmar, Nepal, Niger, Nigeria, Somalia, South Africa, South Sudan, Tanzania, Uganda, and Zambia, and Syria.

Cholera Cases in the U.S.

With modern water systems, there are now typically fewer than 20 cholera cases a year. Nearly all cholera cases reported in the U.S. are acquired during international travel. As of May 2025, there were (1) cholera cases reported in the U.S. As of December 31, 20224, week #52, eight cholera cases were reported to the CDC this year. In 2023, there were 17 cases, and in 2022, the CDC confirmed that eight travelers infected with cholera arrived from Pakistan, Iraq, and Bangladesh. Additionally, the CDC's Clinician Outreach and Communication Alert in 2023 reported an unprecedented global increase in cholera infections.

Cholera Vaccines

As of September 2025, various cholera vaccines have been approved by the WHO but remain in limited availability globally.

2 min read

Reviewer:

Robert Carlson, MD

Last Reviewed:

Monday, September 15, 2025 - 12:20

Description:

Cholera is a vaccine preventable disease causing outbreaks in 2025

Condition:

Cholera

Measles Outbreaks

Measles Outbreaks 2025

The World Health Organization (WHO) reported that measles outbreaks continued in 2025, as 184 WHO Member States reported measles cases. As of May 28, 2025, the U.S. Centers for Disease Control and Prevention (CDC) maintains a global Watch-Level 1, Practice Usual Precautions, Travel Health Notice, identifying measles outbreaks in over 50 countries, which include Afghanistan, Angola, Armenia, Azerbaijan, Benin, Burkina Faso, Burundi, Cameroon, Central African Republic, Chad, Côte d'Ivoire (Ivory Coast), the Democratic Republic of the Congo, Djibouti, Equatorial Guinea, Ethiopia, Gabon, Ghana, India, Indonesia, Kazakhstan, Kazakhstan, Kyrgyzstan, Lebanon, Liberia, Libya, Malaysia, Mauritania, Nepal, Niger, Nigeria, Pakistan, Philippines, Qatar, Republic of South Sudan, Republic of the Congo, Romania, Russia, Senegal, Somalia, Sri Lanka, Sudan, Syria, Tajikistan, Timor-Leste, Togo, Turkey, United Arab Emirates, Uzbekistan, Yemen, and Zambia.

United States Measles Outbreaks 2025

As of December 10, 2025, the CDC reported more than 1,900 confirmed measles cases across 43 US jurisdictions. The CDC issued a Health Alert Network (CDCHAN-00522) on March 7, 2025, regarding measles outbreaks in western Texas. The Texas Department of State Health Services (DSHS) submitted 92 identical DNA sequences in genotype D8, while 10 DNA sequences from New Mexico and one from Kansas were similar to those from Texas. Additionally, five distinct genotype B3 sequences were reported from the States of Alaska, California, Florida, Kentucky, New York, Rhode Island, Texas, and Washington. The Annual Report on Immunization Status of Texas Students for the 2023-2024 School Year indicates a high statewide vaccination rate of over 94%.

United States Measles Outbreaks 2024

As of December 31, 2024, the US CDC reported 285 measles cases (49 imported) in 33 jurisdictions: Arizona, California (San Diego, Los Angeles), Florida (Broward, 10), Georgia, Idaho, Illinois (Chicago (67)), Indiana, Louisiana, Maryland, Michigan, Minnesota (70), Kansas City, Missouri, New Jersey (Camden, Monmouth, Somerset counties), New York (New York City (13)), Nevada, North Carolina, Ohio (Cincinnati), Oregon (31), Pennsylvania (Philadelphia), Tennessee, Virginia, Washington, Washington DC, West Virginia, and Wisconsin. About 56% of cases were hospitalized for management of measles complications, and 39% were under five years of age. As of 2024, there are no CDC recommendations for receiving a third MMR dose during measles outbreaks.

United States Measles Outbreaks 2023

The US CDC reported 59 measles cases in 20 jurisdictions across the United States in 2023. The majority of these cases involved unvaccinated international travelers in California, Colorado, the District of Columbia, Florida, Hawaii, Idaho, Illinois, Kentucky, Maryland, Missouri, New Jersey, New York City, Ohio, Oregon, Pennsylvania, Texas, Utah, Virginia, Washington, and Wisconsin.

United States Measles Outbreaks 2022

According to the CDC, there were 121 measles cases in the US in 2022. Between 2000 and 2022, there was an 18% increase in estimated measles cases and a 43% increase in estimated measles deaths compared with 2021. The Health Department of the City of Columbus, Ohio, and Franklin County Public Health (FCPH) reported 85 confirmed measles cases in children, with 80 of the cases being unvaccinated and 36 resulting in hospitalization.

Measles Outbreak Costs

In April 2021, the journal Pediatrics published a study indicating that treatment costs were $47,479 per hospitalized case during a measles outbreak. In January 2020, Clinical Infectious Diseases published a meta-analysis estimating the median price per hospitalized measles case at $32,805.

Measles Testing

After MMR vaccination, syndromic panels can detect the measles vaccine virus, which is not transmitted to others and does not cause disease in immunocompetent persons. The US CDC reported in March 2024 that among syndromic test panels conducted by a commercial laboratory, approximately 1% were positive for measles. Patients who received these results were children without known measles risk factors who had been vaccinated against measles; the majority <3 Weeks previously. Their results were attributed to the detection of the measles vaccine virus.

Measles Vaccines

During a measles outbreak, the US CDC's Advisory Committee on Immunization Practices (ACIP) outlines cases for administering a third MMR dose.

4 min read

Reviewer:

Robert Carlson, MD

Last Reviewed:

Thursday, December 11, 2025 - 13:55

Description:

Measles detected in Africa, Australia, Brazil, Canada, Caribbean, England, Europe, India, Indonesia, and United States.

Condition:

Measles

West Nile Virus Vaccines

West Nile Virus Vaccine Candidates 2025

The US Food and Drug Administration (FDA) has not approved West Nile virus (WNV) vaccines for use in humans as of December 2025. However, active human clinical studies include vaccine candidates: two live attenuated chimeric vaccines, one DNA vaccine, one recombinant subunit vaccine, and two inactivated whole-virus vaccines. A Research Article published in October 2025 stated that live-attenuated vaccines, including flavivirus YFV 17D and JEV SA14-14-2 vaccines, offer the advantages of robust immune responses and long-lasting protection.

In Phase 2 trials, the live attenuated recombinant yellow fever vaccine strain expressing the premembrane and envelope (prM–E) genes of WNV (ChimeriVax-WN02, Sanofi Pasteur) demonstrated a favorable safety profile and immunogenicity, even in older age groups, following a single dose.

The HydroVax-001 vaccine candidate consists of a hydrogen peroxide-inactivated whole virion (WNV-Kunjin strain) adjuvanted with aluminum hydroxide.

"Our experience over the past two decades has demonstrated that current prevention strategies are insufficient to reduce the ongoing WNV disease burden. WNV vaccination would be more effective in preventing WNV disease and related deaths," wrote a Perspective published by the NEJM on May 4, 2023. "The benefits of live vaccines, including durability of immunity and the need for only one dose, will need to be weighed against potential safety concerns."

2 min read

Reviewer:

Robert Carlson, MD

Last Reviewed:

Wednesday, December 17, 2025 - 15:40

Description:

West nile virus vaccine candidates are conducting clinical trials

Condition:

West Nile Virus

Dengue Outbreaks

Dengue Outbreaks September 2025

According to the World Health Organization (WHO) and numerous health agencies, Dengue is a viral infection spread to humans by infected mosquitoes of the Aedes genus and a leading cause of febrile illness among international travelers in 2025. The WHO has classified Dengue as a grade 3 emergency, with an estimated 4 billion people at risk globally. The WHO states that Dengue is a vaccine-preventable disease, endemic in approximately 110 countries, including areas within the United States, such as Florida and Puerto Rico.

As of August 21, 2025, the WHO Dengue Situation Update 728 indicates that over 6 million Dengue cases and 7,552 related fatalities have occurred in 2025. More than 13 million dengue cases were reported in 2024, marking the highest number of cases on record.

On January 20, 2025, the WHO published a Global Strategic Preparedness, Readiness, and Response Plan for Dengue. Dengue's four subviruses are usually spread to people through the bites of infected Aedes mosquitoes. On October 3, 2024, the WHO launched the Global Strategic Preparedness, Readiness, and Response Plan to tackle Dengue and other Aedes-borne arboviruses. The WHO plan aligns with the Global Vector Control Response 2017-2030, a global strategy to strengthen vector control worldwide, and the Global Arbovirus Initiative.

An analysis published in July 2024 reported that the most frequent regions of dengue infection acquisition were Southeast Asia (50.4%), South Central Asia (14.9%), the Caribbean (10.9%), and South America (9.2%). The median age was 33 years, and tourism was the most frequent reason for travel (67.3%). An analysis published in December 2024 revealed a clear link between climate change and the expansion of vectors, such as mosquitoes, into new territories, increasing disease incidence. Mosquitoes that spread Dengue viruses usually live below 6,500 feet; therefore, a person's chances of getting Dengue in high altitudes are very low.

Dengue Outbreak Travel Advisories

The U.S. Centers for Disease Control and Prevention (CDC) reissued a Global Travel Health Notice on August 21, 2025, regarding Dengue outbreaks in the Americas, Africa/Middle Eas t, and Asia/Pacific regions, such as India, Singapore, Thailand, the Philippines, Malaysia, and Myanmar. The CDC has not issued travel advisories for U.S. states that have reported local dengue outbreaks, such as Florida and Puerto Rico. As of August 2025, HealthMap has published dengue case maps.

Dengue Outbreak in the United States

As of July 2025, the U.S. CDC advises clinicians to consider Dengue in patients with fever who live in or have recently traveled to areas with a risk of Dengue. The CDC reported in September 2025 that 3,045 Dengue cases occurred in 47 jurisdictions this year. The CDC says transmission of Dengue virus serotypes (DENV-1, 2, 3, 4) remains high in the U.S. territories of Puerto Rico and the U.S. Virgin Islands. DENV-3 is the most common (84%) serotype identified in 2025.

In 2024, 53 jurisdictions, led by Arizona, California, Florida, New Jersey, New York, and Puerto Rico, reported 9,391 dengue cases. In June 2024, the CDC issued an updated Health Alert Network Health Advisory, notifying healthcare providers, public health authorities, and the general public of an increased risk of dengue virus infections in the United States. In 2023, 52 U.S. jurisdictions reported 6,164 dengue cases to the CDC.

As of December 2024, the Florida Department of Health (FDH) reported over 999 travel-associated and 91 locally acquired dengue cases throughout the state, with the majority occurring in Miami-Dade County.

The Texas Department of State Health Services (DSHS) reports that mosquitoes that transmit dengue fever are present in the state of Texas. As of September 2025, DSHS reported 31 travel-related dengue cases this year. As of December 2024, there were 43 imported dengue cases in 23 Texas counties, led by Travis County (18), and one local case in Cameron County, with one related fatality. Texas reported 79 travel-related dengue cases in 2023 and one locally acquired case in Val Verde County.

In California, the San Bernardino County Public Health Department reported (1) a locally acquired case of Dengue in San Bernardino on November 7, 2024. The Los Angeles County Department of Public Health has reported 12 locally acquired dengue cases in the San Gabriel Valley , specifically in the cities of Baldwin Park (8), El Monte (2), Hollywood Hills (1), and Panorama City (1), in 2024. Dengue cases were reported in San Diego, Escondido, and Vista in 2024. Over 360 dengue cases were confirmed in California in 2023. California reported two locally acquired cases (in Long Beach and Pasadena) and 250 travel-related cases.

Between 2010 and 2023, 250 locally acquired cases were reported in Hawaiʻi.

Dengue Outbreak U.S. Territories

The CDC says the Dengue virus is endemic in the U.S. territories of Puerto Rico, American Samoa, the U.S. Virgin Islands, the Federated States of Micronesia, the Republic of the Marshall Islands, and the Republic of Palau. On July 7, 2025, American Samoa declared a public health emergency due to a surge in dengue cases. In the U.S. Virgin Islands, a dengue outbreak was declared in August 2024 and remains in effect in 2025. A total of 208 locally acquired cases were identified in 2024 and 30 in 2025, all on the island of St. Croix. The Virgin Islands Department of Health urged residents to take immediate precautions to prevent further dengue transmission as cases surged in the St. Thomas-St. John's area. John's area. John's area. John's area. John's area. John's area. John's area. John's area. John's area. John's area. John and St. Croix Districts.

In March 2024, the Health Ministry declared a public health emergency in Puerto Rico, which remains in effect as of 2025. As of March 7, 2025, 936 cases have been reported, representing a 113% increase compared to the same period in 2024. In 2024, 6,291 cases were reported, and 13 deaths were reported. Puerto Rico's Department of Health confirmed that Dengue was endemic in the greater San Juan area, with 4,467 cases.

Among American Samoa school-aged children, the estimated seroprevalence was 59% for those aged 7–16.

Dengue Outbreaks in Africa

Dengue circulation has been detected in more than 30 African countries. According to the Africa CDC Epidemic Intelligence Report, as of January 2025, over 1,300 dengue cases have been reported in Africa. As of 2024, over 74,000 dengue cases have been reported this year from Burkina Faso, Cameroon, Cabo Verde, Central African Republic, Chad, Côte d'Ivoire, Ethiopia, Ghana, Kenya, Mali, Mauritius, São Tomé and Príncipe, Senegal, Sudan, and Togo. The ACDC reported in 2024 that travelers visiting these African countries may be at an increased risk of Dengue. In 2023, 171,991 dengue cases and 753 deaths were reported in African countries.  The U.S. CDC issued a Travel Health Notice in 2023, confirming Dengue is an ongoing risk in Africa. A December 2025 study found that countries in eastern Africa had a high estimated risk of dengue importation from Asia and other countries in east Africa. In contrast, for West African countries, the risk of importation was higher from within the region than from countries outside of Africa.

Dengue Outbreaks in the Americas

The first suspected dengue-like epidemics were reported in 1635 in Martinique and Guadeloupe. The Pan American Health Organization (PAHO) issued an Epidemiological Alert in February 2025, based on the growing circulation of DENV-3, which had not been circulating previously, thereby increasing the probability of severe cases. In epidemiological week 34 of 2025, a total of 3,740,133 suspected dengue cases were reported. This data represents a 68% decrease compared to the same period in 2024. As of December 31, 2024, 49 countries and territories in the Americas reported over 13,017,982 Dengue cases and 8,151 related deaths in 2024. In 2023, 4,617,108 Dengue cases were reported in the Americas.

Argentina's Epidemiological Bulletin reported over 580,000 dengue cases in 2024, with 56,435 in Buenos Aires. Argentina's Ministry of Health published a Comprehensive Preparedness and Response Plan for Dengue Epidemics 2024-2025.

Over the past 25 years, nearly 18 million Brazilians have contracted one of the four viruses that cause Dengue. Brazil's Ministry of Health reports indicate that, as of 2024, there were over 9.6 million dengue cases and 5,441 related deaths. The São Paulo state dengue data dashboard was updated in May 2025. A study published in The Lancet in March 2025 forecasts that Brazil's Dengue outbreaks will refocus on the southern mountain area. The Brazilian Ministry of Health reported dengue cases among pregnant women reached 5,151 in the first six weeks of 2024, compared to 1,157 in the same period in 2023. In 2023, Brazil reported approximately 2.9 million patients, a 20% increase from the previous year, and Rio de Janeiro reported 22,959 dengue cases.

Dengue is hyperendemic in Colombia. It imposes a substantial economic burden on patients, caregivers, society, and the national health system. In 2025, Colombia's Huila Department declared a public health emergency.

According to the Health Surveillance Directorate of the Republic of Costa Rica, 1,076 dengue cases were reported in 2024. Costa Rica confirmed over 24,000 dengue cases in 2023, with the Huetar Caribe and Central Sur regions reporting the highest number of cases. As of August 4, 2023, all four dengue serotypes were registered.

In French Guyana, over 8,000 confirmed dengue cases have been reported since the beginning of 2024.

The U.S. CDC includes Mexico in its global Level 1 Dengue Travel Health Advisory. As of February 2025, Mexico has reported over 10,000 dengue cases. In 2024, Mexico confirmed about 549,000 dengue cases. A May 2024 model predicted that the percentage of municipalities affected by Dengue would rise from 55 to 91% in Mexico. Dengue was reported in 28 of 32 Mexican states in 2023, and transmission has been documented in Yucatan since 1979. All four DENV serotypes have been found in Mexico for decades. Between 1995 and 2008, constant circulation of DENV-3 was recorded in Mexico. Furthermore, notable increases in circulation were observed in 2022 (25%), 2023 (59%), and 2024 (86%).

In Nicaragua, 92,022 dengue cases were reported in 2024. A study published on January 10, 2025, demonstrates differences in dengue severity by serotype and immune status, emphasizing the critical need for a dengue vaccine with balanced effectiveness against all four serotypes, as existing vaccines show variable efficacy by serotype and serostatus.

DENV was reintroduced in Panama in 1993 after a 35-year absence of autochthonous transmission. All four serotypes were detected in Panama. As of April 2025, Panama reported over 4,800 Dengue cases. An analysis published in 2024 suggests that Panamanian strains were related to viruses from different regions of the Americas, suggesting a continuous exchange of viruses.

Paraguay's Ministry of Health confirmed that the DENV-3 subtype returned in 2025 after a nine-year absence. A study published in May 2025 suggests a high seroprevalence of DENV in Paraguayan blood donors. The high DENV seroprevalence reflects the impact of past Dengue outbreaks.

Peru issued an Alert in November 2024, notifying public and private health facilities of the increased risk of dengue infections. On November 23, 2024, a dengue vaccination program was launched in 16 districts of Loreto, Piura, Tumbes, and Ucayali regions.

On August 16, 2024, the Republic of Trinidad and Tobago confirmed 825 cases of Dengue Fever and eight (8) laboratory-confirmed deaths. The Caribbean reported over 62,000 dengue cases in 2023, a significant increase from 20,349 cases in 2022. Jamaica's Ministry of Health declared a dengue outbreak on September 23, 2023.

Dengue Outbreaks Australia 2025

In Australia, cases of locally acquired Dengue have historically been reported from most mainland Australian states. Dengue notifications have been reported monthly from 2019 to 2025. In January 2025, there were 261 Dengue case notifications. Queensland Health declared a Dengue outbreak centered in the Townsville City Local Government Area (TLGA) on February 19, 2025. As of March 25, 2025, 11 cases (9 confirmed and two probable) had been reported.

Dengue Outbreaks in Asia and the Pacific Islands

In 2025, the WHO confirmed that the Western Pacific Region continues to face a high burden of mosquito-borne arboviral diseases, particularly Dengue. In 2025, the U.S. CDC reported that countries in the WHO Western Pacific Region reported higher-than-usual dengue cases. Travelers visiting the following countries may be at increased risk: Bangladesh, Cambodia, Hong Kong, Indonesia, Fiji, Malaysia, Myanmar, Nepal, the Philippines, Samoa, Singapore, Sri Lanka, Tonga, and Thailand. The WHO publishes Dengue Situation Updates for the Western Pacific Region in 2025.

In 2025, the Cook Islands Ministry of Health declared a dengue fever outbreak in Rarotonga, following confirmation of seven dengue cases.

Fiji Ministry of Health & Medical Services confirmed one Dengue-related fatality on April 7, 2025. Between January and April 15, 2025, approximately 5,100 dengue cases were reported nationwide, with the Western Division leading with 2,077 cases. In 2014, the Fijian Government launched a cleanup campaign to combat the outbreak of dengue fever. Between November 2023 and April 2025, 1,721 dengue cases were reported in French Polynesia.

The Centre for Health Protection (CHP) in Hong Kong reported seven imported cases of dengue fever as of March 20, 2025. In 2024, 161 cases were imported (75 from Mainland China), and five local cases were reported. In 2023, 62 cases of DF were imported from abroad.

In September 2024, the WHO reported that dengue outbreaks in Indonesia (E000099) are at level 4. Dengue virus (DENV) infection is a significant cause of acute febrile illness in Indonesia, a DENV-endemic region that has experienced a 700-fold increase in incidence over the past 45 years. As of July 2024, 149,866 confirmed cases of Dengue and 884 deaths had been reported from 465 districts across 38 provinces in Indonesia.

Data published by the Dengue for Community Portal indicates that Taman Mawar-Sendang was a dengue hotspot in Malaysia in June 2025.

The French Department of Mayotte has confirmed 21 cases of Dengue since the beginning of 2025.

On April 9, 2025, the WHO intervened to prevent dengue outbreaks in Myanmar, distributing 4,500 rapid diagnostic test kits to frontline responders and health workers in displacement sites and remote villages.

The Republic of Nauru Ministry of Health has confirmed 379 dengue cases, and two fatalities were recorded on July 30, 2025.

As of June 20, 2025, the Republic of the Philippines reported about 100,000 dengue cases and a case fatality rate of 0.36%. In 2025, the Quezon City Government in the Philippines, through the City Health Department (QCHD), declared a dengue outbreak. From January to July 2025, the City Epidemiology and Surveillance Division of QCHD reported 5,702 dengue cases. In 2025, a total of 390 dengue cases, along with three deaths, were recorded in Antique. In 2024, the Republic of the Philippines Negros Occidental had 6,799 dengue cases and 22 dengue-related deaths in 2024.

The Independent State of Samoa announced on April 17, 2025, that the Ministry of Health is officially declaring a dengue fever outbreak. As of June 2, 2025, the Ministry of Health reported a total of 211 confirmed cases and one reported death. The majority of cases (76%) are from Upolu Island.

According to Sri Lanka's National Dengue Control Unit, 19,901 dengue cases were reported in the country in 2025.

During the first half of the 20th century, there were three island–wide dengue fever outbreaks in Taiwan. After almost forty years of dormancy, a DEN–2 outbreak occurred in 1981. Since 2006, Taiwan has faced dengue fever outbreaks of different scales every year. As of August 2025, a dengue cluster was reported in Kaohsiung's Gushan District.

Dengue Outbreaks in the Eastern Mediterranean Region

Dengue and severe dengue epidemics were first reported in the WHO's Eastern Mediterranean Region in 1998. Since then, outbreaks have occurred in all nine endemic countries: Afghanistan, Djibouti, Egypt, Oman, Pakistan, Saudi Arabia, Somalia, Sudan, and Yemen. On July 17, 2024, the WHO reported 12 autochthonous (local) cases of Dengue documented in Iran. In August 2024, dengue screening was launched at the Iranian border.

Dengue Outbreaks in Europe

In Europe, dengue viruses, transmitted by Aedes albopictus mosquitoes, are primarily associated with infections acquired in endemic countries. Local transmission remains rare, with only sporadic or small-scale outbreaks documented. As of December 2024, the European Centre for Disease Prevention and Control (ECDC) reported over 8,500 dengue-related deaths. In 2024, the ECDC reported locally acquired dengue cases in France, Germany, Italy, and Spain. Over 1,600 DENV infections in Germany occurred exclusively in travellers returning from dengue-endemic countries in 2024. In 2023, 130 locally acquired dengue cases were reported in the European Union and the European Economic Area (EU/EEA). The number of imported dengue cases in Europe increased from 1,572 in 2022 to approximately 4,900 in 2023.

On July 24, 2025, three confirmed cases of dengue fever were recorded in Budrio, Italy. As of July 15, 2025, Italian health authorities reported the first locally acquired case of Dengue of the year in Italy. The Italian National Public Health Authority reported 213 locally acquired dengue cases in 2024 and 82 cases in 2023. In Fano, a small coastal city in the Marche Region, Eurosurveillance reported 138 confirmed and 61 probable cases of DENV-2 as of October 28, 2024. Travel-related dengue cases have reached 472 in 2024. Non-travel-associated dengue cases have been reported in Italy since 2010, with a total of 10 cases.

On July 15, 2025, a second locally acquired case of Dengue was reported this year in Saint-Chamond, Auvergne-Rhône-Alpes, France. In 2024, France reported 82 locally transmitted cases of dengue fever and over 4,600 imported cases. Outbreaks were identified in the Provence-Alpes-Côte d'Azur, Occitanie, and Auvergne-Rhône-Alpes regions. In 2023, France reported nine dengue outbreaks, which resulted in 45 autochthonous infections. In 2022, France reported 65 locally acquired cases of Dengue.

In February 2025, the Autonomous Region of Madeira (Portugal) reported the results of entomological investigations confirming the presence of Dengue mosquitoes captured on Madeira. Two people were infected. The 2012 dengue outbreak affected approximately 1,000 residents.

Spain reported eight locally acquired dengue cases in the Camp de Tarragona area of the Catalonia region in 2024, and the Catalonia region reported three local cases in 2023.

Dengue Outbreaks in India

India has confirmed Dengue outbreaks for decades. In 2024, over 233,000 Dengue cases and 236 deaths were reported. As of 2024, dengue cases in India are on the rise, particularly in the states of Karnataka, Kerala, and Tamil Nadu. They generally peak in October. According to data from the National Centre for Vector-Borne Diseases Control Program, India reported 289,235 dengue cases and 485 related deaths in 2023. In the Democratic Socialist Republic of Sri Lanka, the co-circulation of multiple dengue virus genotypes was reported in October 2024 to be associated with an increase in cases.

Dengue United Kingdom 2025

The UK Health Security Agency (UKHSA) states that local dengue fever does not occur in the United Kingdom; however, it can be acquired by traveling to dengue-endemic areas. In 2024, 904 dengue cases were reported in returning travellers across England, Wales, and Northern Ireland, up from 631 in 2023. The most significant proportion of English cases (349) was reported in London. This data represents a 201% increase compared to the same period in 2023, which saw 157 cases. In 2024, India remained the most reported travel destination, with 179 cases, a 23% increase compared to 2023.

Dengue Virus-Carrying Mosquito

Mosquito bites cause more human suffering than any other organism. The spread of Dengue throughout the world can be directly attributed to the proliferation and adaptation of these mosquitoes. In the U.S., there are 176 species. A recent study published by the Royal Society indicates that dengue-carrying mosquitoes are expanding their range by an average of 6.5 meters of elevation and have moved polewards by 4.7 km annually.

Dengue Virus Infection Testing

The U.S. Centers for Disease Control and Prevention (CDC) published a Health Update (CDCHAN-00523) on March 18, 2025, highlighting the ongoing risk of Dengue virus infections and updates to testing recommendations in the United States. People with suspected Dengue virus infection should be tested with a real-time PCR, NS1 antigen test, or an IgM enzyme-linked immunosorbent assay antibody test at commercial labs or public health clinics.

Dengue Disease

Dengue is a disease caused by a virus transmitted through the bites of infected mosquitoes. It can take up to two weeks to develop, but the illness generally lasts less than a week. Without treatment, severe Dengue can become fatal. New research has identified pre-existing anti-DENV IgG antibodies as the cause of the increased duration of Dengue upon second exposure.

Severe Dengue

Approximately 5% of Dengue cases can progress rapidly to Severe Dengue, which may involve hypovolemic shock, gastrointestinal or vaginal bleeding requiring transfusion, and end-organ impairment. Furthermore, women infected with Dengue during pregnancy can pass the virus to their fetuses. Promptly initiating intensive supportive therapy can reduce the risk of death among patients with severe Dengue. The extent and duration of viremia are often correlated with the severity of clinical disease. A study published in October 2024 concluded that secondary dengue infections with different dengue virus serotypes have been linked to an increased risk of Severe Dengue after two years.

Dengue Infections Cause Cardiovascular Complications

Published on April 18, 2025, this review discusses the cardiovascular manifestations of Dengue and their management, explores the proposed pathogenesis, and concludes with a discussion of potential future research directions.

Dengue Viruses

There are four Dengue Viruses. A study published in October 2024 concluded that the co-circulation of multiple genotypes is associated with an increase in severe cases, highlighting the importance of continuous surveillance.

Dengue Virus Blood Transfusion-Transmission

Emerging evidence published in November 2024 suggests a potentially concerning route of blood transfusion-transmitted dengue virus (TT-DENV), which poses a critical threat, especially in endemic countries like Brazil. In May 2024, a RESEARCH ARTICLE found that dengue virus transmission was a risk in blood donation in Thailand. In March 2016, Transfusion-Transmitted Dengue and Associated Clinical Symptoms During the 2012 Epidemic in Brazil was published.

Dengue Infection Immune-Mediated Enhancement

In this study, published on October 31, 2024, researchers demonstrate that the expression of a DENV-specific B cell receptor (BCR) renders cells highly susceptible to DENV infection, with the infection-enhancing activity of the membrane-restricted BCR correlating with the antibody-dependent enhancement (ADE) potential of the IgG version of the antibody. In addition, they observed that the frequency of DENV-infectible B cells increases in previously flavivirus-naïve volunteers after a primary DENV infection. These findings suggest that BCR-dependent infection of B cells is a novel mechanism for immune-mediated enhancement of DENV infection. This observation indicates that BCR-dependent infection of DENV-specific B cells may be a complementary mechanism for immune-mediated enhancement of DENV infection, expanding upon existing models of antibody-dependent enhancement.

Dengue Outbreak Discrepancy Research

In October 2024, a study published by The Lancet Infectious Diseases provided novel insights into serotype-specific epidemiological patterns and disease outcomes of primadengue virus (rDENV)ENV infections by revealing the hidden contribution of inapparent infections. This indicates that case surveillance skews the perceived epidemiological footprint of Dengue's four viruses. On October 25, 2024, these researchers wrote, 'While inapparent infections are often overlooked and do not require immediate medical attention, we have assumed that they account for up to 88% of all dengue virus (DENV) transmission events. A study published in May 2024 revealed substantial discrepancies between estimates and reported numbers of dengue cases. A study published in the journal Nature on January 20 revealed variations in antibody composition that contribute to the miscounting of primary and secondary infections.

Dengue Virus in Pregnant Women

The CDC confirms that a pregnant woman already infected with Dengue can pass the virus to her child during pregnancy, and there has been one documented report of Dengue spread through breast milk. A study published in the American Economic Journal: Applied Economics in April 2024 confirmed robust evidence for the adverse effect of dengue infections on birth weight and documented increases in children's hospitalizations and medical expenditures for up to three years after birth.

Dengue and Zika Virus

A study published in the journal Science Translational Medicine on May 29, 2024, found that primary ZIKV infection increased the risk of disease caused by DENV3 and DENV4 but not DENV1. This finding was also observed for tertiary infections in individuals previously infected with DENV and ZIKV, but not in those previously infected with ZI alone.

Dengue Vaccines

Information on dengue vaccines (Qdenga), vaccine candidates, and clinical trials in 2025 can be found at Vax-Before-Travel.

21 min read

Reviewer:

Robert Carlson, MD

Last Reviewed:

Wednesday, September 17, 2025 - 04:55

Description:

Dengue outbreaks in Africa, Asia, Brazil, California, Caribbean, China, Costa Rica, Florida, France, India, Italy, Jamaica, Mexico, Spain, Thailand.

Vaccine:

QDENGA Dengue Vaccine