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Following the declaration of the Sudan Ebolavirus (SVD) outbreak in late January 2025, the Republic of Unganda's Ministry of Health recently reported an additional positive case in Mulago hospital who passed away on February 25, 2025.

As of early March 2025, there have been ten confirmed cases, including two related fatalities. Out of the ten confirmed SVD cases, five are health workers, and four are family members of the index case.

Additionally, nearly 300 close contacts were identified.

The World Health Organization recently wrote, 'The confirmation of a new SVD case in Kampala highlights the risk of undetected transmission, particularly given the delayed diagnosis and the child's movement across multiple healthcare facilities.'

The United Nations in Uganda has also launched an appeal to raise funds for the comprehensive three-month (March- May) response plan, seeking $11.2 million.

Future interventions will focus on seven very high-risk districts, with potential expansion to other districts based on the needs and resources in alignment with the national response plan.

"The goal is to rapidly contain the outbreak and address its impact on public health as well as associated social-economic life of affected people, in full solidarity with the Government and people of Uganda," said WHO Representative Dr. Kasonde Mwinga in a press release on March 3, 2025.

Uganda has experienced five previous SVD outbreaks.

Additionally, traveler screening at 13 Ugandan entry points remains active, with 25,364 travelers screened as of March 2, 2025. Ugandan passengers are also subject to virus screening when arriving in the United States.

Currently, there are approved vaccines and therapies for Zaire Ebolavirus but not for Sudan.

However, over 2,000 doses of IAVI's rVSV Sudan ebolavirus vaccine candidate (IAVI C108, rVSVΔG-SUDV-GP) were shipped to Uganda in early 2025. Theuse of these vaccines is being evaluated in a clinical trial.

In addition to an Ebola Travel Health Advisory, the U.S. CDC has issued polio and mpox alerts focused on Uganda in 2025. The CDC says that approved vaccines are available at travel clinics and pharmacies to prevent these diseases.

Vaccine Treats: 
Sudan Ebolavirus
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Image Caption: 
US CDC 2025
Live Blog Update Author: 
Don Hackett
Location Tags: 
Uganda
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The state of Texas has been reporting a spike in measles cases in 2025, including some in vaccinated children.

The Texas Department of State Health Services (DSHS) initially reported two measles cases in Harris County, which includes the city of Houston, in January 2025.

Since then, DSHS has confirmed an ongoing measles outbreak in the South Plains. As of March 4, 2025, 159 cases have been identified. There has been one fatality in a school-aged child who lived in the outbreak area. The child was not vaccinated and had no known underlying conditions.

Another measles case was recently reported in Travis County by the Austin Health Department.

The DSHS's investigation into the vaccination status is ongoing. So far, 5 cases have been confirmed as vaccinated with one dose. In 74 cases, the vaccination status is classified as unknown.

DSHS wrote, 'A dose of MMR is given to unvaccinated people within 72 hours of their exposure to the measles to lessen the severity of the illness if they get sick from the virus.'

'We are investigating whether any of these cases received their MMR dose after (virus) exposure.'

'Due to the highly contagious nature of this disease, additional cases are likely to occur in the outbreak area and the surrounding communities,' added DSHS.

Last year, 285 measles cases were reported in the U.S. Minnesota (70) and Illinois (67) were the leaders in confirming measles outbreaks.

Most of the measles cases in 2024 were traced to unvaccinated international travelers.

Currently, the U.S. CDC maintains a Level 1 Travel Health Advisory that identifies 57 countries reporting measles cases.

The CDC and DSHS strongly encourage most people to get two doses of a MMR vaccine, available at clinics and pharmacies in the United States in 2025.

Measles vaccination programs began in the United States in 1963. Since then, the MMR vaccine has been found to be very safe and about 95% effective.

The U.S. FDA has approved the M-M-R®II, ProQuad®, and Priorix vaccines to prevent measles. On November 18, 2022, the CDC stated that the Priorx and M-M-R II® vaccines are considered fully interchangeable.

Vaccine Treats: 
Measles
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Image Caption: 
US CDC Feb. 2025
Live Blog Update Author: 
Don Hackett
Location Tags: 
Austin
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The British Territory of the Turks and Caicos Islands in the Bahamas is just a quick 620-mile flight from the United States. It offers warm Caribbean waters and a safe vaccination.

The country's tourism authority, Experience Turks and Caicos, recently confirmed that about two million travelers visited the islands in 2024, setting a new record.

According to the U.S. Department of State's updated Level 2: Exercise Increased Caution for the Turks and Caicos Islands, the U.S. Embassy in Nassau provides consular services for U.S. citizens.

The U.S. Embassy consular personnel will visit Providenciales, Turks, and the Caicos Islands from March 5 to March 7, 2025, to provide routine U.S. passport and citizenship services.

On March 4, 2025, the State Department wrote that vacationers should avoid Providenciales, as that was where most of the crime occurred. Providenciales is the third largest island in the Turks and Caicos, home to most of the population.

Furthermore, the Provo area has resorts and hotels that line the island's beautiful coastline.

From a health-risk perspective, Turks and Caicos has avoided most mosquito-transmitted disease outbreaks except for Dengue. In 2024, 117 cases were reported.

The UK Travel Health Pro writes that a dengue vaccine is licensed in the UK to prevent dengue disease in individuals from 4 years of age. However, there are no certificate requirements under the International Health Regulations.

The U.S. CDC does suggest various travel and routine vaccinations before traveling to the islands. These vaccines are offered at travel clinics and pharmacies in the U.S.

Vaccine Treats: 
Dengue
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Image Caption: 
Google Maps 2025
Live Blog Update Author: 
Karen McClorey Hackett
Location Tags: 
The Bahamas
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UTI Appointment Request Response

As you may be aware, the Uromune MV140 vaccine is not FDA-approved for use in the United States as of October 2025. However, this oral spray UTI vaccine is available 'off-label' in various countries.

  • In Canada, Red Leaf Medical has voluntarily withdrawn the application to address deficiencies in the submission identified by Health Canada.
  • In Mexico, the Benavides pharmacy website lists Uromune, but inventory has been limited, and you need a local doctor's prescription. Several other pharmacies in Mexico also offer Uromune.
  • In England, clincis near London offers the UTI vaccine, such as The Urology Partnership at The Forbury Clinic.
  • In Portugal, Dr. Ricardo Pereira e Silva and collaborators the Hospital de Santa Maria – Lisbon. Online interview link.
  • According to the manufacturer, Uromune is not offered in Spain.
  • In the Dominican Republic, here is the contact for Luis E. Betances & Co. SAS.
  • Across the Pacific, this clinic at Mount Elizabeth Novena Hospital and Uro Health in Singapore offer UTI services.
  • Uromune is not yet approved in Denmark, France, Germany, India or Japan.

Additionally, here is a link to UTI information about:

  1. Uro-Vaxom® (OM-89) whose active ingredient is the bacterial lysate acts as a vaccine. Since its launch, millions of patients have been treated with OM-89.
  2. Blujepa is approved for the treatment of female adults (≥40 kg) and pediatric patients with uUTIs.
  3. Pivya (pivmecillinam) tablets for Uncomplicated UTIs.
  4. RECCE 327 is an intravenous and topical UTI therapy.
  5. Complicated urinary tract infections (cUTIs) pivotal Phase 3 clinical trial announced positive data. If approved, tebipenem HBr could be the first oral carbapenem antibiotic for patients with cUTIs.
  6. The BCG vaccine is used off-lable for various bacteria related infections.
  7. LBP-EC01 is a bacteriophage cocktail engineered with a CRISPR-Cas3 construct targeting the E. coli genome, treating uncomplicated UTIs.
  8. UTI clinical trials in the USA.

In addition to UTIs, Vax-Before-Travel publishes breaking news and travel vaccine information.

By the way, I am not a healthcare provider, and this publicly available information is not health advice. If you have questions, please contact your healthcare provider.

Thank you,

Don

Donald W. Hackett

Publisher, Vax-Before-Trave LLC

@DonWardHackett

3 min read
Last Reviewed: 
Sunday, October 12, 2025 - 05:00
Description: 
Uromune UTI Vaccine October 2025
Condition: 
Urinary Track Infection (UTI)
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While the mpox Clade 2 outbreak has spread globally since May 2022, Clade 1 cases have been limited to travel-related detections in most countries.

According to the South Africa's Department of Health's announcement on February 27, 2025, the country has recorded three laboratory-confirmed cases of mpox Clade 1 in three provinces, such as Gauteng. 

Gauteng province contains the country's largest city, Johannesburg, home to about 16 million people.

This news increases the cumulative number of positive cases from 25 to 28, including three deaths.

The DOH wrote in a press release, 'There is no need for the public to panic, but people are urged to remain cautious of how mpox spreads and to seek help when faced with symptoms of mpox.'

'The risk of wider transmission remains low in South Africa, but anyone can contract mpox regardless of age, gender, sexual orientation and race.'

Mpox has become a vaccine-preventable disease.

However, South Africa has a limited stock of a mpox-specific vaccine for the treatment of patients who experience severe health complications as a result of this sexually transmitted disease.

As of March 4, 2025, about four mpox vaccines have been used worldwide.

Globally, mpox continues to be a Public Health Emergency of International Concern and a Public Health Emergency of Continental Security, as per the declarations by both the World Health Organization and Africa Centres for Disease Control and Prevention in August 2024.

The mpox outbreak is ongoing in thirteen out of 22 countries in Africa, with Uganda and the Democratic Republic of Congo currently reporting the highest number of cases.

In the United States, most Clade 1 mpox cases have been travel-related.

Vaccine Treats: 
mpox
Image: 
Image Caption: 
Google Maps March 4, 2025
Live Blog Update Author: 
Don Hackett
Location Tags: 
South Africa
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malaria

Africa's Unknown Disease Outbreak Remains Undetermined

Severe malaria related to the DRC's fatal outbreak in 2025
March 4, 2025
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While no area within the United States has officially been declared endemic of Dengue, Florida's Health Department has continued to report both locally acquired and travel-related cases in 2025.

As of March 4, 2025, Florida's latest Arbovirus Surveillance update disclosed thirty-two cases of dengue reported among persons who had traveled internationally. These cases are in Lake, Collier, Hillsborough (2), Marion, Miami-Dade (19), Okeechobee (3), Orange (2), Palm Beach (2), and St. Lucie counties.

As of December 2024, 999 travel-associated dengue cases had been reported, mainly among Brazil, Cuba (567), and Puerto Rico visitors.

In 2024, 91 locally acquired dengue cases were reported from ten counties, such as Miami-Dade (50), Hillsborough (Tampa), Manatee, Monroe, Orange, Pasco (13), and Broward.

Most of these dengue cases are serotyped as DENV-3 and 4.

As of 2025, the U.S. Centers for Disease Control and Prevention, Canada, and the United Kingdom have not issued travel alerts or vaccination requirements for visiting Florida. However, Miami-Dade County is currently under a mosquito-borne illness alert.

These agencies do recommend avoiding mosquito bites while visiting Florida, as Dengue vaccines are unavailable in the U.S.

Vaccine Treats: 
Dengue
Image: 
Image Caption: 
Florida Health Dept. 2025
Live Blog Update Author: 
Don Hackett
Location Tags: 
Miami
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Oropouche Virus Has Spread Throughout the Americas

Oropouche travel advisories active in 2025
March 4, 2025
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As the 2024-2025 flu season winds down in the United States, the U.S. CDC recently reported positive news regarding this year's influenza vaccine effectiveness (VE).

On February 27, 2025, the CDC announced that the interim 2024–2025 seasonal influenza VE estimates among children and adolescents were 32%, 59%, and 60% in outpatient settings and 63% and 78% against influenza-associated hospitalization.

Among adults, VE was 36% and 54% in outpatient settings and 41% and 55% against influenza-associated hospitalization.

The CDC wrote that this data indicated 'vaccination with the 2024–2025 influenza vaccine reduced the risk for influenza-associated outpatient visits and hospitalization.'

Unfortunately, twelve pediatric deaths associated with seasonal influenza virus infection were reported last week, bringing the 2024-2025 season total to 98 pediatric deaths.

Last flu season, 207 children died from influenza infections.

These CDC findings support the recommendation that all eligible persons aged ≥ over six months receive an annual influenza vaccination.

From an availability perspective, with over 100 million vaccines distributed this season, flu shots should be offered at clinics and pharmacies as long as influenza viruses are circulating.

Vaccine Treats: 
Influenza
Image: 
Image Caption: 
US CDC 2025
Live Blog Update Author: 
Don Hackett
Location Tags: 
Atlanta
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Costa Rica Visitors Confront Perpetual Tourism Rules and Infected Mosquitoes

Costa Rica confirmed Chikungunya, dengue, malaria and Zika Cases in 2025
March 3, 2025