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The World Health Organization (WHO) recently published update Edition #139 on the COVID-19 pandemic.
As of April 20, 2023, the WHO confirmed new COVID-19 cases and deaths decreased by 27% and 32%, respectively, compared to the previous month.
Contrary to the overall global trend, significant increases were seen in some WHO regions and countries, such as the South-East Asia Region (+654%), which includes India.

The U.S. Department of State issued a Level 4: Do Not Travel advisory for the Republic of Sudan in northeast Africa.
Announced on April 22, 2023, the travel alert confirmed the U.S. Embassy in Khartoum suspended its operations.
In addition, the State Department ordered the departure of U.S. direct-hire employees and eligible family members from the Embassy in Khartoum due to the continued civil unrest.
Specifically, the U.S. government cannot provide routine or emergency consular services to U.S. citizens in Sudan due to the current security situation.
We are aware of convoys departing Khartoum traveling towards Port Sudan. However, the Embassy cannot assist convoys, and traveling in any convoy is at your own risk, wrote the Embassy.
And if you travel to Sudan, exercise extreme care in all parts of the country, including Khartoum. Unfortunately, Khartoum's airport was closed due to the uncertain security situation.
Additionally, visitors are encouraged to enroll in the Smart Traveler Program to receive Alerts during an emergency.
From a health perspective, the U.S. CDC issued various travel alerts for Sudan's measles, polio, and dengue outbreaks.
Travel vaccination services are offered in Texas at local clinics and community pharmacies.

The World Health Organization (WHO) recently reported that the Republic of Indonesia's polio outbreak risk was assessed as high at the national level.
As of April 17, 2023, the WHO says the current polio outbreak in Indonesia poses a moderate regional risk and a low risk globally.
These assessments are related to the Indonesia Ministry of Health notifying the WHO of the detections of a circulating vaccine-derived poliovirus type 2 (cVDPV2) and acute flaccid paralysis (AFP) from the Purwakarta district in West Java province.
A total of four confirmed cases of VDPV2 have been reported in Indonesia since November 2022.
This includes three cases of cVDPV2 with AFP in Aceh province and one in West Java province.
Additionally, four healthy children in Aceh province were confirmed to have cVDPV2 on November 25, 2022.
Despite Indonesia having a strong capacity to respond to poliovirus outbreaks, there is a high susceptibility of the population to poliovirus type 2 after switching from trivalent to bivalent OPV.
WHO's International Travel and Health recommends that all travelers to polio-affected areas be fully vaccinated against polio.
And the WHO does not recommend any travel and/or trade restrictions to Indonesia based on the current information available for this event.
Indonesia has been included in recent U.S. CDC travel alerts for measles and polio.
In the U.S., polio vaccines are offered at health clinics and pharmacies in Texas.

The U.S. CDC's Weekly U.S. Influenza Surveillance Report published today highlighted negative news regarding influenza-associated pediatric mortality.
During Week #15, two influenza-associated pediatric deaths that occurred during the 2022-2023 season were reported this week.
This data increases the total number of pediatric flu deaths reported during the 2022-2023 flu season to 143.
Throughout the COVID-19 pandemic, there were very few pediatric deaths reported.
Pre-pandemic, during the 2019-2020 flu season, 199 deaths were confirmed by the CDC.
The positive news posted by the CDC on April 21, 2023, is the majority of influenza viruses tested are in the same genetic subclade as and antigenically similar to the influenza viruses included in this flu season's influenza vaccines.
The CDC continues to recommend that everyone ages six months and older get an annual flu vaccine as long as flu activity continues in the U.S.
As of March 4, 2023, the CDC reported that about 173 million flu shots had been distributed this flu season, about the same as 2021-2022.
And flu shots are advised for those traveling to countries where influenza cases have been reported, such as Brazil, Belize, Guatemala, Peru, and Europe.

Aptitude Medical Systems today announced that it had received an award of up to $53.7 million from the U.S. government. The funding supports the development of over-the-counter molecular diagnostics capable of delivering lab-quality results in 15-30 minutes while approaching the cost of antigen tests.
About $19.6 million in funding is targeted to develop and validate at-home COVID and COVID/Flu tests.
And up to $34.1 million was allocated for options to develop additional multiplex tests for other infectious disease threats.
Aptitude aims to make molecular tests as accessible as antigen tests according to JP Wang, Ph.D., Aptitude CSO and co-founder, in a press release on April 20, 2023. "The value of that upgrade is clear – a PCR-quality molecular test means that you can detect infection earlier to avoid spreading to your family, friends, and coworkers."
This work is funded in whole or in part with federal funds from the Department of Health and Human Services; Administration for Strategic Preparedness and Response; Biomedical Advanced Research and Development Authority, under contract number 75A50123C00013.

The Government of Western Australia (WA) recently confirmed a case of measles was identified in a returned overseas traveler.
According to the Department of Health, on April 20, 2023, this was the first measles case reported in WA in more than three years.
And if you attended the exposure sites during the listed dates, you may have been exposed to this very transmissible virus and should monitor for symptoms.
People with measles typically develop symptoms around ten days after exposure, and rashes usually appear four to five days after symptoms start showing.
Globally, measles cases increased by about 80% last year compared with 2021, says the U.S. Centers for Disease Control and Prevention (CDC).
The CDC's top ten global measles outbreak list is led by India.
To alert international travelers of their measles risk, the CDC reissued its Watch - Level 1, Practice Usual Precautions notice on April 6, 2023.
Vaccination with a measles-containing vaccine is the best way to ensure you are protected, says the CDC.
For travelers 12 months or older, two doses at least 28 days apart are recommended.
In the U.S., measles vaccines are offered at health clinics and pharmacies in cities such as Austin, Houston, and Lubbock, Texas.

Th World Health Organization (WHO) today announced that while the COVID-19 pandemic is diminishing in some countries, in other parts of the world, new cases and related fatalities increased last month.
Published on April 20, 2023, the WHO's Weekly Epidemiological Update Edition #139 on COVID-19 reported new cases, and deaths decreased by 27% and 32%, respectively, compared to the previous 28 days.
Unfortunately, the United States of America (USA) is a leader in both categories.
This is partly due to the reductions in testing and delays in reporting in many countries, wrote the WHO.
At the country level, the highest numbers of new 28-day cases were reported from the USA (432,798 new cases; -45%), the Republic of Korea (+6%), France (+65%), and Brazil (+35%).
The highest numbers of new 28-day deaths were reported from the USA (5,559 new deaths; -32%), Brazil (-26%), Germany (-58%), and the Islamic Republic of Iran (+193%).
From a vaccination perspective, fewer COVID-19 vaccines were administered last month.
However, India began reordering various non-mRNA vaccines in April 2023.
And in the USA, the government expanded access to bivalent mRNA COVID-19 vaccines on April 18, 2023,
As of April 16, 2023, a total of 13,322,849,443 COVID-19 vaccine doses have been administered globally during the pandemic.
