First-In-Human Study To Evaluate Safety, Tolerability, And Pharmacokinetics Following Single Ascending And Multiple Ascending Doses of PF-07304814 In Hospitalized Participants With COVID-19.

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It is a 2-part study in 72 hospitalized COVID-19 patients.

Part 1 is to evaluate the safety, tolerability, PK, and markers of clinical activity of escalating doses of PF-07304814 given as 24-hour IV infusion.

2 planned and 3 optional cohorts with 8 participants each are planned.

Part 2 is to evaluate the safety, tolerability, PK, and markers of clinical activity of escalating doses of PF- 07304814 given as 120-hour infusion.

2 planned and 2 optional cohorts with 8 participants each are planned